Polysaccharide-block-polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids
Polysaccharide-block-polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids
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DOI：
10.1002/anie.200805895
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Lecommandoux, Sebastien
中科院分区：
文献类型：
--
作者：
Schatz, Christophe;Louguet, Stephanie;Lecommandoux, Sebastien
自然灵感：两亲性多糖-嵌段-多肽共聚物是通过点击化学合成的，由末端功能化为炔基的葡聚糖和末端功能化为叠氮基的聚（γ-苄基L-谷氨酸）组成。这些共聚物自组装成小囊泡的能力（见图）表明了新一代药物和基因递送系统的可能性，其结构模仿病毒的结构。
Natural inspiration: Amphiphilic polysaccharide‐block‐polypeptide copolymers were synthesized by click chemistry from dextran end‐functionalized with an alkyne group and poly(γ‐benzylL‐glutamate) end‐functionalized with an azide group. The ability of these copolymers to self‐assemble into small vesicles (see picture) suggests the possibility of a new generation of drug‐ and gene‐delivery systems whose structure mimics that of viruses.