Apolipoprotein E genotype and gallbladder disease risk in a large population-based cohort
Apolipoprotein E genotype and gallbladder disease risk in a large population-based cohort
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DOI：
10.1016/j.annepidem.2006.04.005
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发表时间：
2006-10-01
影响因子：
5.6
通讯作者：
Boerwinkle, Eric
中科院分区：
文献类型：
--
作者：
Boland, Lori L.;Folsom, Aaron R.;Boerwinkle, Eric
目的：研究载脂蛋白E （apoE）基因型与胆囊疾病发病率之间的关系。方法：参与社区动脉粥样硬化风险研究（ARIC）的近13,000名中年男性和女性的住院胆囊疾病病例被确定，这是一项在美国四个社区进行的前瞻性队列研究。结果：在ARIC基线检查（1987 - 1989）至2001年12月31日期间，共有639名参与者因胆囊疾病住院。在调整了年龄、性别、种族、肥胖、血脂水平和糖尿病等因素后，与epsilon 4等位基因（即E4/4、E3/4和E2/4基因型与其他基因型）存在相关的住院胆囊疾病的相对风险为0.72（95%可信区间[CI]， 0.60-0.87）。种族分层显示，白人与epsilon 4的负相关（相对危险度，0.69;95% CI, 0.56-0.85）强于非裔美国人（相对危险度，0.86;95% CI, 0.58-1.30）。另一种罕见亚型epsilon 2（即E2/2、E2/3和E2/4基因型相对于其他基因型）的存在与胆囊疾病的风险适度增加相关（相对风险为1.28；95% CI为1.05-1.57）。结论：这些结果表明，与传统的危险因素无关，载脂蛋白e基因型可能影响胆囊疾病的风险，尤其是在白人中。这种关联的确切生物学机制尚不清楚，需要进一步研究。
PURPOSE: The aim of the study is to describe the association between apolipoprotein E (apoE) genotype and gallbladder disease incidence.METHODS: Cases of incident hospitalized gallbladder disease were ascertained in nearly 13,000 middle-aged men and women participating in the Atherosclerosis Risk in Communities (ARIC) Study, a prospective cohort study in four US communities.RESULTS: Between the ARIC baseline examination (1987 to 1989) and December 31, 2001, a total of 639 participants were hospitalized for gallbladder disease. After adjustment for age, sex, race, obesity, plasma lipid level, and diabetes, the relative risk for hospitalized gallbladder disease associated with the presence of an epsilon 4 allele (i.e., genotypes E4/4, E3/4, and E2/4 versus other genotypes) was 0.72 (95% confidence interval [CI], 0.60-0.87). Stratification by race showed that the inverse association with epsilon 4 was stronger in whites (relative risk, 0.69; 95% CI, 0.56-0.85) than African Americans (relative risk, 0.86; 95% CI, 0.58-1.30). The presence of the other rare isoform, epsilon 2 (i.e., genotypes E2/2, E2/3, and E2/4 versus others) was associated with a modest increased risk for gallbladder disease (relative risk, 1.28; 95% CI, 1.05-1.57).CONCLUSIONS: These results suggest that independent of traditional risk factors, apoE genotype may influence gallbladder disease risk, particularly in whites. The exact biologic mechanism for such an association remains unclear and requires further investigation.