Highly Stereoselective 7-Endo-Trig/Ring Contraction Cascade To Construct Pyrrolo[1,2-a]quinoline Derivatives
Highly Stereoselective 7-Endo-Trig/Ring Contraction Cascade To Construct Pyrrolo[1,2-a]quinoline Derivatives
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高立体选择性 7-Endo-Trig/环收缩级联构建吡咯并[1,2-a]喹啉衍生物
DOI：
10.1021/ol100220c
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发表时间：
2010-04-16
期刊：
影响因子：
5.2
通讯作者：
Hong, Ran
中科院分区：
文献类型：
--
作者：
Li, Xinyu;Li, Cheng;Hong, Ran
在Cram's phenonium离子的协同作用下，通过一种新的级联反应，以良好到优异的产率构建了吡咯并[1，2-a]喹啉的唯一非对映异构体。初步的机理研究表明，γ-内酰胺环和富电子芳烃是环收缩的重要驱动力。
With the cooperation of Cram's phenonium ion, a novel cascade reaction was illustrated to construct pyrrolo[1,2-a]quinolines as a sole diastereoisomer in good to excellent yields. Preliminary mechanistic studies revealed that the gamma-lactam ring and electron-rich arene are important driving forces for ring contraction.