Islet Transplantation With Immunoisolation
Islet Transplantation With Immunoisolation
复制标题
免疫隔离胰岛移植
作者：
R. Lanza;S. Sullivan;W. Chick
免疫隔离是一种潜在的重要方法，移植胰岛，而不需要免疫抑制药物。已经设想了免疫隔离系统，其中移植的组织通过人工屏障与宿主的免疫系统分离。这些系统通过允许使用从动物胰腺分离的胰岛提供了对人类胰岛获取问题的解决方案。所使用的装置被称为生物混合人工器官，因为它们结合了联合收割机合成的、选择性渗透的膜，该膜可以阻止活体移植的免疫排斥反应。已经研究了三种主要类型的生物混合胰腺装置。这些包括作为AV分流器、扩散室和微囊而被附接到血管系统的装置。在糖尿病啮齿动物和狗中的结果表明，生物混合胰腺装置显着改善葡萄糖稳态，并可以发挥作用超过一年。最近取得的进展，这种方法进行了讨论，并解决了一些剩余的问题，必须解决，使这项技术的临床现实。
Immunoisolation is a potentially important approach to transplanting islets without need for immunosuppressive drugs. Immunoisolation systems have been conceived in which the transplanted tissue Is separated from the immune system of the host by an artificial barrier. These systems offer a solution to the problem of human islet procurement by permitting use of Islets Isolated from animal pancreases. The devices used are referred to as biohybrid artificial organs because they combine synthetic, selectively permeable membranes that block immune rejection with living transplants. Three major types of biohybrid pancreas devices have been studied. These include devices anastomosed to the vascular system as AV shunts, diffusion chambers, and microcapsules. Results In diabetic rodents and dogs indicate that biohybrid pancreas devices significantly improve glucose homeostasis and can function for more than a year. Recent progress made with this approach is discussed, and some of the remaining problems that must be resolved to bring this technology to clinical reality are addressed.
离体大鼠朗格汉斯胰岛刺激胰岛素分泌的氧和温度依赖性。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Ohta,M;Nelson,D;Nelson,J;Meglasson,MD;Erecińska,M
通讯作者：
Erecińska,M
与使用 FK 506 相关的不良反应。
影响因子：
0.9
作者：
Fung,JJ;Alessiani,M;Abu-Elmagd,K;Todo,S;Shapiro,R;Tzakis,A;VanThiel,D;Armitage,J;Jain,A;McCauley,J
通讯作者：
McCauley,J