Loss of imprinting in hepatoblastoma.
Loss of imprinting in hepatoblastoma.
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发表时间：
1995-05
期刊：
影响因子：
11.2
通讯作者：
Shirley Rainier;Craig Dobry;Andrew P. Feinberg
中科院分区：
文献类型：
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作者：
Shirley Rainier;Craig Dobry;Andrew P. Feinberg
我们和其他人已经描述了胰岛素样生长因子II （IGF2）基因印迹缺失（LOI）在70%的Wilms肿瘤（WT），一种胚胎性肾肿瘤，我们也发现了29%的WTs中H19基因的LOI。在WT中，IGF2的LOI与H19的下调相耦合。IGF2的LOI随后在第二种胚胎性肿瘤横纹肌肉瘤中被描述。然而，一份在3例肝母细胞瘤中缺乏LOI的报告对LOI是胚胎性肿瘤的普遍特征的假设提出了挑战（S. M. Davies, Cancer, 53: 4781-4783, 1993）。我们鉴定了5个肝母细胞瘤，为IGF2基因的转录多态性提供了信息。1例肿瘤显示IGF2失活，与先前报道相反。该肿瘤也显示出H19的LOI，进一步证明了该基因在癌症印记干扰中的作用。然而，与WT相比，肝母细胞瘤的LOI与H19的下调无关。因此，IGF2和H19的表达可以在LOI肿瘤中解耦。
We and others have described loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene in 70% of Wilms' tumors (WT), an embryonal kidney tumor, and we have also found LOI of the H19 gene in 29% of WTs. In WT, LOI of IGF2 is coupled to down-regulation of H19. LOI of IGF2 has subsequently been described in a second embryonal neoplasm, rhabdomyosarcoma. However, the hypothesis that LOI is a general feature of embryonal tumors is challenged by a report of absence of LOI in three hepatoblastomas (S. M. Davies, Cancer Res., 53: 4781-4783, 1993). We identified five hepatoblastomas informative for a transcribed polymorphism of the IGF2 gene. One tumor showed LOI of IGF2, in contrast to the previous report. That tumor also showed LOI of H19, further documenting a role for this gene in imprinting disturbances in cancer. However, in contrast to WT, LOI in hepatoblastoma was not associated with down-regulation of H19. Thus, IGF2 and H19 expression can be uncoupled in tumors with LOI.