Development of Functional Properties in the Early Visual System: New Appreciations of the Roles of Lateral Geniculate Nucleus.
Development of Functional Properties in the Early Visual System: New Appreciations of the Roles of Lateral Geniculate Nucleus.
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DOI：
10.1007/7854_2021_297
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发表时间：
2022-02
影响因子：
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通讯作者：
Andrea K. Stacy;Stephen D. Van Hooser
中科院分区：
文献类型：
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作者：
Andrea K. Stacy;Stephen D. Van Hooser
在Hubel和Wisel首次报道眼优势可塑性和弱视后的几年里，人们一直关注于了解皮质环路在发育和经验依赖性可塑性中的作用。初步研究发现，视网膜神经节细胞和外侧膝状体神经元之间几乎没有区别，也没有发现多少证据表明视觉体验改变对外侧膝状体神经元的功能特性有影响。然而，在过去的二十年里，研究表明，视网膜和外侧膝状体之间的连接比人们之前所认识的要丰富得多，甚至揭示了外侧膝状体神经元的视觉可塑性-包括眼睛优势可塑性-。在这里，我们回顾了早期视觉系统的发展和经验的影响，特别是最近关于外侧膝状核的发现，它的连接性，以及它在发育过程中可塑性和僵硬的证据。
In the years following Hubel and Wiesel’s first reports on ocular dominance plasticity and amblyopia, much attention has been focused on understanding the role of cortical circuits in developmental and experience-dependent plasticity. Initial studies found few differences between retinal ganglion cells and neurons in the lateral geniculate nucleus and uncovered little evidence for an impact of altered visual experience on the functional properties of lateral geniculate nucleus neurons. In the last two decades, however, studies have revealed that the connectivity between the retina and lateral geniculate nucleus is much richer than was previously appreciated, even revealing visual plasticity – including ocular dominance plasticity – in lateral geniculate nucleus neurons. Here we review the development of the early visual system and the impact of experience with a distinct focus on recent discoveries about lateral geniculate nucleus, its connectivity, and evidence for its plasticity and rigidity during development.