A prospective pilot study of antibodies against human papillomaviruses and cutaneous squamous cell carcinoma nested in the Oxford component of the European Prospective Investigation into Cancer and Nutrition
A prospective pilot study of antibodies against human papillomaviruses and cutaneous squamous cell carcinoma nested in the Oxford component of the European Prospective Investigation into Cancer and Nutrition
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DOI：
10.1002/ijc.22885
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发表时间：
2007-10-15
影响因子：
6.4
通讯作者：
Newton, Robert
中科院分区：
文献类型：
--
作者：
Casabonne, Delphine;Michael, Kristina M.;Newton, Robert
在一项嵌套在EPIC-Oxford队列中的前瞻性先导性研究中，我们检测了39例皮肤鳞状细胞癌(SCC)患者和80例对照组中38种人乳头瘤病毒(HPV)L1抗原抗体的血清阳性率。15例在采血时已发生鳞状细胞癌(流行)的患者也进行了检测。在发病病例和对照组之间，针对所检查的任何HPV类型的抗体的血清阳性率在统计学上没有显著差异，在多重感染的血清阳性率方面也没有差异。然而，与已发表的病例对照研究结果一致的是，流行病例中许多β-HPV类型的血清阳性率高于发病病例或对照。例如，对照组HPV-8抗体阳性率为20%(16/80)，发病病例为23%(9/39)，流行病例为40%(6115)。在仅发生的病例中，在确诊前18个月以上采集血液的患者中，血清阳性率为16%(5/32)，但在采集血液后18个月内确诊的患者中，血清阳性率为57%(4/7)，这一模式在许多HPV类型中都可以看到。这可能表明，如果HPV参与了鳞状细胞癌的病因学，这个过程发生在接近诊断的时候，或者在鳞状细胞癌患者中观察到的抗体反应是肿瘤形成的结果。需要更多更大规模的前瞻性研究来阐明HPV在皮肤鳞状细胞癌病因学中的作用。(C)2007年Wiley-Liss，Inc.
In a prospective pilot study nested in the EPIC-Oxford cohort, we examined the seroprevalence of antibodies against the L1 antigen of 38 human papilloma virus (HPV) types among 39 cases of cutaneous squamous cell carcinoma (SCC) for whom plasma was collected prior to diagnosis (incident) and 80 controls. Fifteen cases having already developed SCC at blood collection (prevalent) were also tested. There were no statistically significant differences in the seroprevalence of antibodies against any of the HPV types examined between incident cases and controls, nor was there a difference in the seroprevalence of multiple infections. However, consistent with results from published case-control studies, the seroprevalence of many beta-HPV types was higher among prevalent cases than among either incident cases or controls. For example the seroprevalence of antibodies against HPV-8 was 20% (16/80) in controls, 23% (9/39) among incident cases and 40% (6115) among prevalent cases. Among the incident cases only, the seroprevalence was 16% (5/32) among those for whom blood was collected 18+ months prior to diagnosis, but 57% (4/7) among those for whom diagnosis was within 18 months of blood collection, a pattern seen for many of the HPV types. This might suggest that if HPV is involved in the aetiology of SCC, the process occurs close to the time of diagnosis, or that the antibody response observed in people with SCC is a consequence of tumor formation. Further and larger prospective studies are needed to clarify the role of HPV in the aetiology of cutaneous SCC. (C) 2007 Wiley-Liss, Inc.