Brain Activation and Gait Alteration During Cognitive and Motor Dual Task Walking in Stroke-A Functional Near-Infrared Spectroscopy Study
Brain Activation and Gait Alteration During Cognitive and Motor Dual Task Walking in Stroke-A Functional Near-Infrared Spectroscopy Study
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DOI：
10.1109/tnsre.2018.2878045
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发表时间：
2018-12-01
影响因子：
4.9
通讯作者：
Lu, Chia-Feng
中科院分区：
文献类型：
--
作者：
Liu, Yan-Ci;Yang, Yea-Ru;Lu, Chia-Feng
本文研究了认知和运动双重任务对中风患者步态表现和脑活动的影响。23名中风受试者以自选速度分别进行了单走、边走边执行认知任务和边走边执行运动任务。记录步态表现，包括速度、节奏、步态时间、步长和双任务成本(DTC)。采用功能性近红外光谱分析技术，检测行走过程中大鼠前额叶皮质、前运动皮质(PMC)和辅助运动区(SMA)的脑活动。结果显示，与西南状态相比，WCT和WMT的速度、节奏和步长均显著降低，而步态时间显著延长。WCT组与WMT组DTC差异无统计学意义。在WCT和WMT期间，非病变的SMA和双侧PMCs的大多数通道的Hb差异指数均显著高于SW。此外，在不同的步行任务中，步态表现与双侧PMC和受损的SMA呈负相关。总而言之，在尝试双重任务的中风患者中，步态表现恶化。两种双重任务在步态表现上没有显著差异。然而，SMA尤其是PMC在卒中后认知和运动双重任务行走中起着关键作用。
This paper investigated the effects of cognitive and motor dual tasks on gait performance and brain activities in stroke; 23 stroke subjects performed single walking (SW), walking while performing cognitive task (WCT), and walking while performing motor task (WMT) at self-selected speed. The gait performance was recorded, including speed, cadence, stride time, stride length, and dual task cost (DTC). Brain activities in prefrontal cortex, premotor cortex (PMC), and supplementary motor areas (SMAs) were measured by functional near-infrared spectroscopy during walking. Results showed significant decrease in speed, cadence, and stride length, and increase in stride time was noted in both WCT and WMT compared with SW condition. There was no significant difference in DTC between WCT and WMT. The non-lesioned SMA and most channels of bilateral PMCs exhibited significant increases in the index of hemoglobin differential during WCT and WMT compared with SW. Moreover, gait performance was negatively correlated with bilateral PMCs and lesioned SMA during different walking tasks. In conclusion, deteriorated gait performance was noted in stroke attempting dual tasks. There is no significant difference between the two dual tasks on gait performance. Nevertheless, SMA and especially PMC were crucial in cognitive and motor dual task walking after stroke.