Stromal directives can control cancer.
Stromal directives can control cancer.
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基质指令可以控制癌症。
DOI：
10.1126/science.aaw2368
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Gascard,Philippe
中科院分区：
文献类型：
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作者：
Tlsty,TheaD;Gascard,Philippe
有充分证据表明，炎症过程和信号传导在大多数癌症的进展中发挥着关键作用 (1)，尤其是作为慢性损伤部位的有效引发剂 (2)。在这些慢性炎症相关癌症 (CIAC) 中，组织损伤是由持续或反复感染、刺激或创伤引起的。这一类独特的恶性肿瘤包括胃酸反流相关的食管腺癌 (EAC)、吸烟相关的肺鳞状细胞癌、幽门螺杆菌感染相关的胃腺癌和炎症性肠病相关的结肠腺癌，占全球所有癌症死亡的 20% 至 25%，每年导致超过 200 万人死亡。与其他肿瘤类型相比，CIAC 的预后往往较差，这归因于其高转移倾向和耐药性。慢性炎症促进此类致命癌症发展的潜在机制仍知之甚少。
There is ample evidence that inflammatory processes and signaling play a critical role in the progression of most cancers (1), especially as potent initiators at sites of chronic injury (2). In these chronic inflammation–associated cancers (CIACs), tissue injury is caused by sustained or recurrent infection, irritation, or trauma. This distinct class of malignancies, which includes acid reflux–associated esophageal adenocarcinoma (EAC), smoking-associated lung squamous cell carcinoma,Helicobacter pyloriinfection–associated gastric adenocarcinoma, and inflammatory bowel disease–associated colon adenocarcinoma, is responsible for 20 to 25% of all cancer deaths worldwide, killing more than 2 million people annually. Compared with other tumor types, CIACs tend to have a poorer prognosis, attributable to a high propensity for metastasis and drug resistance. The underlying mechanisms by which chronic inflammation promotes the development of such lethal cancers are still poorly understood.