Early detection of bronchial lesions using newly developed videoendoscopy-based autofluorescence bronchoscopy
Early detection of bronchial lesions using newly developed videoendoscopy-based autofluorescence bronchoscopy
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DOI：
10.1016/j.lungcan.2005.11.009
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发表时间：
2006-04-01
期刊：
影响因子：
5.3
通讯作者：
Aoki, Y
中科院分区：
文献类型：
--
作者：
Ikeda, N;Honda, H;Aoki, Y
据报道，白色光和自体荧光支气管镜检查的组合在检测支气管发育不良和癌症方面显示出比单独使用白色光更好的灵敏度。然而，纤维支气管镜检查在大多数领先机构已被视频内窥镜检查取代超过十年。为了避免中断视频内窥镜检查以进行基于纤维镜的自体荧光检查以及提高上皮内病变的灵敏度，创建了集成到视频内窥镜（SAFE 3000，Pentax，Tokyo）中的自体荧光诊断系统。共154例连续患者使用该系统进行了研究，其中包括83例已知或疑似肺癌病例，46例痰细胞学异常，10例肺癌手术后随访病例，15例重度吸烟者有呼吸道症状。不正常.在166个部位通过白色光和/或SAFE 3000识别结果，并进行活检以评估内窥镜结果与病理结果之间的关系。该系统对CIS +异型增生的灵敏度在白色光下为65%，在SAFE光下为90%。这种基于视频内窥镜的自发荧光系统对上皮内病变的敏感性明显高于单独的白色光视频内窥镜。(c)2006 Elsevier Iretand Ltd.保留所有权利。
The combination of white light and autofluorescence bronchoscopy has been reported to show better sensitivity in detecting dysplasia and cancer of the bronchus than white light alone. However, fiberoptic bronchoscopy has been replaced by videoendoscopy at most leading facilities for over a decade. To avoid interruption of the videoendoscopy examination to perform fiberscopy-based autofluorescence examination as well as enhancing the sensitivity of intraepithetial lesions, autofluorescence diagnosis system integrated into a videoendoscope (SAFE 3000, Pentax, Tokyo) was created. A total of 154 consecutive patients were studied using this system, containing 83 known or suspected tung cancer cases, 46 of the cases with abnormal sputum cytology findings, 10 follow up cases following lung cancer operations, and 15 heavy smokers with respiratory symptoms. Abnormal. findings were recognized by white light and/or SAFE 3000 at 166 sites and biopsies were taken to evaluate the relationship between endoscopic findings and pathology results. The sensitivity of the system for CIS + dysplasia was 65% in white light and 90% in SAFE. This videoendoscopy-based autofluorescence system had significantly higher sensitivity for intraepithelial lesions than white light videoendoscopy alone. (c) 2006 Elsevier Iretand Ltd. All rights reserved.