Vasogenic edema and VEGF expression in a rat two-vein occlusion model.
Vasogenic edema and VEGF expression in a rat two-vein occlusion model.
复制标题
大鼠两静脉闭塞模型中的血管源性水肿和 VEGF 表达。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
T. Tsuji
中科院分区：
文献类型：
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作者：
R. Kimura;H. Nakase;T. Sakaki;T. Taoka;T. Tsuji
血管源性水肿在脑静脉循环障碍（CVCD）的发病机制中起重要作用。由于血管内皮生长因子（VEGF）是血管生成和血管通透性的主要介质，包括诱导血管源性水肿，因此本研究旨在研究其是否与CVCD相关。使用雄性Wistar大鼠（n = 15）。使用玫瑰红染料和光纤照明光化学地封闭两个相邻的皮质静脉，24小时后通过磁共振成像（MRI）进行评价。MRI后立即从颅骨中取出每个脑，并对切片进行苏木精-伊红染色（H&E染色），以进行组织病理学检查并与MRI数据进行比较。血管内皮生长因子的表达，如证明化学似乎符合血管源性水肿，诊断为水的表观扩散系数（ADCw）地图上的高强度区域。根据这些数据，我们认为VEGF与CVCD急性期血管源性水肿的形成有关。
Vasogenic edema plays an important etiologic role in the pathogenesis of cerebral venous circulation disturbances (CVCDs). Since vascular endothelial growth factor (VEGF) is a major mediator in angiogenesis and vascular permeability, including induction of vasogenic edema, the present study was undertaken to investigate whether it has any relevance to CVCDs. Male Wistar rats (n = 15) were used. Two adjacent cortical veins were occluded photochemically using rose bengal dye and fiberoptic illumination, with evaluation 24 hours thereafter by magnetic resonance imaging (MRI). Each brain was removed from the skull immediately after MRI and processed for hematoxylin-eosin staining (H&E staining) of sections for histopathology and comparison with MRI data. VEGF expression as demonstrated immunohistochemically appeared to coincide with vasogenic edema, diagnosed as high intensity areas on apparent diffusion coefficient of water (ADCw) maps. On the basis of these data, we conclude that VEGF is related to formation of vasogenic edema in the acute stage of CVCD.
影响因子：
15.9
作者：
Zhang, ZG;Zhang, L;Chopp, M
通讯作者：
Chopp, M