FDG PET in Detecting Primary and Recurrent Malignant Salivary Gland Tumors
FDG PET in Detecting Primary and Recurrent Malignant Salivary Gland Tumors
复制标题
FDG PET 在检测原发性和复发性恶性唾液腺肿瘤中的应用
作者：
T. Çermik;A. Mavi;Gunsel Acikgoz;M. Houseni;S. Dadparvar;A. Alavi
目的：本研究的目的是评估PET在原发性恶性唾液腺（SG）肿瘤患者治疗中的作用。材料和方法：回顾性分析了48例恶性SG肿瘤患者（中位年龄58岁，范围28-89岁，女性20例，男性28例）的61例FDG PET检查。13名患者被转诊进行初步诊断和分期，而在随访期间，48名患者怀疑复发和/或转移性疾病。结果如下：在PET检查的13例患者的初始表现，12例显示在原发灶的摄取增加，而传统的方法（CT，MRI）是积极的11例，2例是模棱两可的。PET检查发现6例多发淋巴结转移和2例远处转移。常规方法证实其中5例有淋巴结转移。在随访患者组中，4例（8%）局部复发患者和4例（8%）转移性疾病患者的PET不准确（假阴性或阳性）。然而，15例（31%）复发研究和7例（15%）转移研究采用常规放射学方法为假阴性。PET检测复发疾病的敏感性、特异性、阳性和阴性预测值分别为83%、93%、63%和98%;常规方法分别为67%、69%、24%和94%。PET检测转移性疾病的总体敏感性、特异性、阳性预测值和阴性预测值分别为93%、96%、82%和99%，而常规方法的敏感性、特异性、阳性预测值和阴性预测值分别为80%、95%、75%和96%。结论：这些结果表明，FDG PET不仅是上级CT和/或MRI分期在初始表现，但也上级常规成像方法检测局部复发和区域淋巴结和远处转移的恶性SG肿瘤患者。
Purpose: The aim of this study was to assess the role of PET in the management of patients with primary malignant salivary gland (SG) tumor. Material and Methods: Sixty-one FDG PET studies in 48 patients (median age 58, range 28–89 years, 20 female, 28 male) who were diagnosed with malignant SG tumors were retrospectively analyzed. Thirteen were referred for initial diagnosis and staging while there was a suspicion of recurrence and/or metastatic disease in 48 patients during the follow-up period. Results: On PET examinations of 13 patients on initial presentation, 12 showed increased uptake in the primary lesion, while conventional methods (CT, MRI) were positive in 11 and were equivocal for 2 patients. Six patients with multiple nodal and 2 patients with distant metastases were detected by PET. Conventional methods demonstrated lymph node metastases in 5 of these patients. In the follow-up patient group, PET was inaccurate (false-negative or positive) in 4 (8%) patients with local recurrence, and in 4 (8%) with metastatic disease. However, 15 (31%) studies for recurrence and 7 (15%) for metastasis were false-negative with conventional radiologic methods. The sensitivity, specificity, and positive and negative predictive values for the detection of recurrent disease were 83%, 93%, 63%, and 98% for PET; 67%, 69%, 24%, and 94% for conventional methods, respectively. Overall sensitivity, specificity, positive and negative predictive values of PET for detecting metastatic disease were 93%, 96%, 82%, and 99%, while those of conventional methods were 80%, 95%, 75%, and 96%, respectively. Conclusion: These results demonstrate that FDG PET is not only superior to CT and/or MRI for staging at the initial presentation but also superior to conventional imaging methodologies for detecting local recurrence and regional lymph node and distant metastases in patients with malignant SG tumor.
影响因子：
7.7
作者：
Wahid，Muqeet;Saqib，Fatima;Gandara，Jesus Simal
通讯作者：
Gandara，Jesus Simal