INCREASED BIRTH-WEIGHT AFTER PRENATAL DIETARY SUPPLEMENTATION OF RURAL AFRICAN WOMEN
INCREASED BIRTH-WEIGHT AFTER PRENATAL DIETARY SUPPLEMENTATION OF RURAL AFRICAN WOMEN
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DOI：
10.1093/ajcn/46.6.912
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发表时间：
1987-12-01
影响因子：
7.1
通讯作者：
WHITEHEAD, RG
中科院分区：
文献类型：
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作者：
PRENTICE, AM;COLE, TJ;WHITEHEAD, RG
197名冈比亚农村妇女在4年期间接受能量密集产前膳食补充剂（净摄入量= 430千卡/天）的体重数据与182名妇女4年基线的数据进行了比较。干预前出生体重平均为2944 .+-。43（SEM）g，当妇女在干收获季节处于正能量平衡时（妊娠体重增加> 1200 g/mo）。体重下降到2808 .+-。41克（p < 0.01），在雨季，当食物短缺和农业工作造成负平衡（体重增加< 500克/月）。基线数据中没有可检测到的长期趋势。补充在旱季无效，但在雨季非常有效：+225 .+-。56 g，p < 0.001（未调整）或+200 . ±。53 g，p < 0.001（经性别、季节和产次调整），通过儿童间多元回归分析; +231 .+-. 65 g，经母亲内分析，p < 0.001。低出生体重婴儿（< 2501 g）的比例从23.7%下降到7.5%，p < 0.002。观察到的临界效应强调了有选择地针对真正处于危险中的群体采取干预措施的重要性。
Birthweight data from 197 rural Gambian women who received an energy-dense prenatal dietary supplement over a 4-y period (net intake = 430 kcal/d) was compared with data from 182 women from 4 baseline years. Preintervention birthweights averaged 2944 .+-. 43 (SEM) g when women were in positive energy balance during the dry harvest season (pregnancy weight gain > 1200 g/mo). Birthweights decreased to 2808 .+-. 41 g (p < 0.01) in the wet season when food shortages and agricultural work caused negative balance (weight gain < 500 g/mo). There were no detectable secular trends in the baseline data. Supplementation was ineffective during the dry season but highly effective during the wet season: +225 .+-. 56 g, p < 0.001 (unadjusted) or +200 .+-. 53 g, p < 0.001 (adjusted for sex, season, and parity) by between-child multiple regression analysis; +231 .+-. 65 g, p < 0.001 by within-mother analysis. The proportion of low-birthweight babies (< 2501 g) decreased from 23.7-7.5%, p < 0.002. The observed threshold effect emphasizes the importance of selective targeting of interventions to truly at-risk groups.