Paying the brain's energy bill.
Paying the brain's energy bill.
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支付大脑的能量账单。
DOI：
10.1016/j.conb.2022.102668
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发表时间：
2023
影响因子：
5.7
通讯作者：
Padamsey Z
中科院分区：
文献类型：
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作者：
Padamsey Z
在自然界中，卡路里的供应是不稳定和短暂的，动物是如何设法维持代谢昂贵的大脑的？在这里，我们回顾了支持三种策略的研究，包括：1）从外周组织和功能重新分配能量以支付大脑的成本，2）实施节能神经编码，使大脑能够以降低的能量成本运行，3）在食物短缺期间有效利用昂贵的神经资源。总的来说，这些研究揭示了一套异质的节能机制，使能源昂贵的大脑适合生存。
How have animals managed to maintain metabolically expensive brains given the volatile and fleeting availability of calories in the natural world? Here we review studies in support of three strategies that involve: 1) a reallocation of energy from peripheral tissues and functions to cover the costs of the brain, 2) an implementation of energy-efficient neural coding, enabling the brain to operate at reduced energy costs, and 3) efficient use of costly neural resources during food scarcity. Collectively, these studies reveal a heterogeneous set of energy-saving mechanisms that make energy-costly brains fit for survival.