Ambient air pollution and congenital heart disease: A register-based study
Ambient air pollution and congenital heart disease: A register-based study
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DOI：
10.1016/j.envres.2011.01.022
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发表时间：
2011-04-01
影响因子：
8.3
通讯作者：
Pless-Mulloli, Tanja
中科院分区：
文献类型：
--
作者：
Dadvand, Payam;Rankin, Judith;Pless-Mulloli, Tanja
孕妇暴露于环境空气污染越来越多地与不良妊娠结局有关。将这种暴露与先天性异常联系起来的证据仍然有限且有争议。本病例对照研究调查了英格兰东北部人群中母亲暴露于空气动力学直径小于10 μ m的颗粒物（PM（10））、二氧化硫（SO（2））、二氧化氮、一氧化氮（NO）、臭氧（O（3））和一氧化碳（CO）与先天性心脏病发生之间的关系（1993-2003）。每个病例和对照组被分配每周平均（怀孕3-8周）的污染物水平测量的最接近的监测母亲的住宅邮政编码。使用暴露作为连续变量和分类变量，构建logistic回归模型，以量化暴露于空气污染物和每个结果组的发生率的调整后的比值比。我们发现暴露于CO和NO与室间隔缺损和心间隔畸形有关。CO也与先天性肺动脉瓣狭窄相关，NO与先天性心脏病和法洛四联症合并病例相关。SO（2）、O（3）和PM（10）的结果不太一致。(C)2011 Elsevier Inc. All rights reserved.
Maternal exposure to ambient air pollution has increasingly been linked to adverse pregnancy outcomes. The evidence linking this exposure to congenital anomalies is still limited and controversial. This case-control study investigated the association between maternal exposure to ambient particulate matter with aerodynamic diameter less than 10 mu m (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide, nitric oxide (NO), ozone (O(3)), and carbon monoxide (CO) and the occurrence of congenital heart disease in the population of Northeast England (1993-2003). Each case and control was assigned weekly average (weeks 3-8 of pregnancy) of pollutant levels measured by the closest monitor to the mother's residential postcode. Using exposure as both continuous and categorical variables, logistic regression models were constructed to quantify the adjusted odds ratios of exposure to air pollutants and the occurrence of each outcome group. We found exposure to CO and NO to be associated with ventricular septal defect and cardiac septa malformations. CO was also associated with congenital pulmonary valve stenosis and NO with pooled cases of congenital heart disease and tetralogy of Fallot. Findings for SO(2), O(3) and PM(10) were less consistent. (C) 2011 Elsevier Inc. All rights reserved.