Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions
Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions
复制标题
DOI：
10.1007/s12185-017-2261-x
复制
发表时间：
2017-07-01
影响因子：
2.1
通讯作者：
Takubo, Keiyo
中科院分区：
文献类型：
--
作者：
Karigane, Daiki;Takubo, Keiyo
造血干细胞（HSCs）具有多向分化和自我更新的功能，在生物体的一生中维持整个造血系统。这些能力是由内在的转录程序和来自微环境或生态位的外在线索维持的。最近的研究使用代谢组学技术揭示，代谢调节在HSC维持中起着至关重要的作用。代谢途径提供能量和其他因素在稳态和压力下发挥作用的基石。在这里，我们回顾了最近的进展，我们的理解代谢调控相关的细胞周期静止，对称/不对称分裂，增殖后的压力和谱系承诺，并讨论了治疗潜力的靶向代谢因子或途径，以治疗血液恶性肿瘤。
Hematopoietic stem cells (HSCs) exhibit multilineage differentiation and self-renewal activities that maintain the entire hematopoietic system during an organism's lifetime. These abilities are sustained by intrinsic transcriptional programs and extrinsic cues from the microenvironment or niche. Recent studies using metabolomics technologies reveal that metabolic regulation plays an essential role in HSC maintenance. Metabolic pathways provide energy and building blocks for other factors functioning at steady state and in stress. Here we review recent advances in our understanding of metabolic regulation in HSCs relevant to cell cycle quiescence, symmetric/asymmetric division, and proliferation following stress and lineage commitment, and discuss the therapeutic potential of targeting metabolic factors or pathways to treat hematological malignancies.