Lattice simulations of phase morphology on lipid bilayers: renormalization, membrane shape, and electrostatic dipole interactions.
Lattice simulations of phase morphology on lipid bilayers: renormalization, membrane shape, and electrostatic dipole interactions.
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DOI：
10.1103/physreve.89.022702
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Feigenson GW
中科院分区：
文献类型：
--
作者：
Amazon JJ;Feigenson GW
当液相在平衡状态下共存，但不被驱动以使域界面接触能最小化时，所得到的相域图案对活细胞可能具有重要意义。在这项研究中，我们探讨了一些相互作用和条件，产生稳定的模式相，观察模型脂质混合物。通过使用蒙特卡罗模拟，我们发现背景曲率对于图案化（调制）相位的形成很重要。稳定纳米级相分离的相互作用仍然没有得到很好的理解。我们发现，包含一个静电偶极子排斥与衰减长度短至2至4个脂质直径可以打破域在纳米尺度上，并且该位置的可折叠性临界点是敏感的这种相互作用。粗粒度模拟的使用提出了在不同长度尺度下执行的模拟中比较参数的问题。使用重整化群技术，我们展示了如何调和这个问题，治疗线张力作为一个运行的耦合常数。
When liquid phases coexist at equilibrium but are not driven to minimize domain interfacial contact energy, the resulting patterns of phase domains can have important implications for living cells. In this study we explore some of the interactions and conditions that produce the stable patterned phases that are observed in model lipid mixtures. By use of Monte Carlo simulations we find that background curvature is important for the formation of patterned (modulated) phases. The interactions that stabilize nanoscopic phase separation are still not well understood. We show that inclusion of an electrostatic dipole repulsion with decay lengths as short as two to four lipid diameters can break up domains at the nanometer scale and that the location of the miscibility critical point is sensitive to this interaction. The use of a coarse-grained simulation raises questions about comparing parameters in simulations performed at different length scales. Using renormalization group techniques we show how to reconcile this problem, treating line tension as a running coupling constant.