MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION EFFICIENCY AND PHARMACOKINETICS OF PHOTOSENSE : A NEW LIPOSOMAL PHOTOSENSITIZER FORMULATION BASED ON ALUMINUM SULFOPHTHALOCYANINE
MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION EFFICIENCY AND PHARMACOKINETICS OF PHOTOSENSE : A NEW LIPOSOMAL PHOTOSENSITIZER FORMULATION BASED ON ALUMINUM SULFOPHTHALOCYANINE
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发表时间：
2005
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通讯作者：
Z. Smirnova;N. Oborotova;O. A. Makarova;O. Orlova;A. P. Polozkova;I. Kubasova;E. Luk’yanets;G. Meerovich;N. I. Zimakova;S. G. Kuz’min;G. Vorozhtsov;A. Baryshnikov
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作者：
Z. Smirnova;N. Oborotova;O. A. Makarova;O. Orlova;A. P. Polozkova;I. Kubasova;E. Luk’yanets;G. Meerovich;N. I. Zimakova;S. G. Kuz’min;G. Vorozhtsov;A. Baryshnikov
本文研究了一种新的基于硫酞菁铝盐的光敏剂脂质体形式（LF）的光动力学活性和药代动力学，并与代表母体物质0.2%水溶液的标准形式（SF）进行了比较。光感LF对埃利希氏瘤小鼠的有效治疗剂量为1 mg kg，是SF有效剂量的四分之一。给药24 h后，光感LF在肿瘤组织中的蓄积选择性是SF的1.5倍。实验第7天，光感组LF在皮肤中的药物蓄积（以荧光强度测定）比SF低1.6倍。光感LF在无肿瘤小鼠体内的药代动力学与SF的行为有显著差异。
The photodynamic activity and pharmacokinetics of a new liposomal form (LF) of the sensitizer Photosense based on aluminum sulfophthalocyanine salts have been studied in comparison to those of the standard form (SF) representing a 0.2% aqueous solution of the parent substance. The effective therapeutic doze of the LF of Photosense in mice bearing Ehrlich’s tumor was 1 mg kg, which is four times as small as the effective dose of the SF. The selectivity of accumulation in the tumor tissue 24 h after administration for the LF of Photosense was 1.5 times higher than for the SF. The drug accumulation in skin (determined by the fluorescence intensity) on the 7th days of experiment for the LF of Photosense was 1.6 times lower than for the SF. The pharmacokinetics of the LF of Photosense in mice without tumors significantly differs from the behavior of the SF.