HUMAN B-CELL DIFFERENTIATION FACTOR DEFINED BY AN ANTIPEPTIDE ANTIBODY AND ITS POSSIBLE ROLE IN AUTOANTIBODY PRODUCTION
HUMAN B-CELL DIFFERENTIATION FACTOR DEFINED BY AN ANTIPEPTIDE ANTIBODY AND ITS POSSIBLE ROLE IN AUTOANTIBODY PRODUCTION
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DOI：
10.1073/pnas.84.1.228
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发表时间：
1987-01-01
影响因子：
11.1
通讯作者：
KISHIMOTO, T
中科院分区：
文献类型：
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作者：
HIRANO, T;TAGA, T;KISHIMOTO, T
测定了人B细胞分化因子或B细胞刺激因子2（BSF-2）的氨基端部分氨基酸序列。针对对应于NH 2末端序列的残基1-13的合成肽产生的抗体与由T细胞系和由植物血凝素刺激的正常T细胞产生的BSF-2特异性反应。此外，抗肽抗体与心脏粘液瘤以及子宫颈癌细胞产生的BSF-2样因子反应。结果表明，BSF-2在体内也发挥作用，并提示BSF-2的组成性产生可能参与了自身抗体的产生，因为心脏粘液瘤和子宫癌患者显示了自身抗体的产生。
The partial amino acid sequence ofthe NH2 terminus of a factor named human B-cell differentiation factor or B-cell stimulatory factor 2 (BSF-2) has been determined. Antibodies raised against the synthetic peptide corresponding to residues 1-13 of the NH2-terminal sequence specifically react with BSF-2 generated by a T-cell line and by phytohemagglutinin-stimulated normal T cells. Furthermore, the antipeptide antibodies react with a BSF-2-like factor produced by cardiac myxoma as well as uterine cervical carcinoma cells. The results show that BSF-2 functions in vivo as well and suggest that the constitutive production of BSF-2 maybe involved in autoantibody production, since patients with cardiac myxoma and uterine carcinoma showed autoantibody production.