The growth and involution of lymphatic tissue and its interrelationships to aging and to the growth of the adrenal glands and sex organs in CBA mice
The growth and involution of lymphatic tissue and its interrelationships to aging and to the growth of the adrenal glands and sex organs in CBA mice
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CBA小鼠淋巴组织的生长和退化及其与衰老、肾上腺和性器官生长的相互关系
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发表时间：
1960
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影响因子：
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通讯作者：
G. Santisteban
中科院分区：
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作者：
G. Santisteban
自从帕尔图夫(1880-1890)发展了淋巴-黄体构成的理论，“胸腺淋巴状态”，人们已经了解了许多关于胸腺的正常变化，这种变化发生在人类和低等动物中，随着年龄的增长而发生(Waldeyer，1890；Hammar，‘06；Jackson，’13；Boyd，‘32)。然而，由于淋巴结和弥漫淋巴组织的广泛分布，很难获得关于动物体内总淋巴组织正常生长和退化的准确数据，也很难将胸腺和淋巴结的正常年龄变化与其他组织和器官的生长联系起来。Hellman(‘14)尝试在兔身上研究淋巴结和胸腺的正常生长，Reinhardt(’46)在大鼠和Gyllensten(‘53)在豚鼠上进行了较小程度的研究。近年来，肾上腺皮质激素和报警刺激对小鼠淋巴组织质量和细胞学的影响受到了广泛的研究(Dougherty，‘52；Santisteban and Dougherty，’54；Santisteban and Swinard，‘56；Santisteban，’55，‘56，’58，‘59)。在这些研究中，使用相同年龄和性别的动物，通过采样几个淋巴器官并将其与正常比较，来分析整个淋巴组织对各种实验条件的反应。有大量证据表明，胸腺的生长和退化也受到垂体、甲状腺和性腺因素的影响(Dougherty，‘52；Shrewsbury and Reinhardt，’55)。然而，关于年龄和性别对小鼠淋巴组织生长的影响的完整分析尚未见报道。本文研究了年龄、性别和肾上腺对胸腺和有代表性的淋巴结生长和退化的影响。这是通过将不同类型淋巴器官重量的变化与年龄和性别的差异以及一般身体生长和生殖器组织和肾上腺的生长相关联来实现的。这些结果为研究年龄和性别对肾上腺切除术后淋巴组织生长的影响提供了基础。后者正在单独报告。
Since Paltouf ( 1880-1890) developed the theory of the lymphatic-chlorotic constitution, "the status thymicolymphaticus," much has been learned about the normal changes in the thymus which occur with increasing age in both human and lower animals (Waldeyer, 1890; Hammar, '06; Jackson, '13; Boyd, '32). However, the wide-spread distribution of lymph nodes and diffuse lymphatic tissue has made it difficult to obtain accurate data concerning the normal growth and involution of the total lymphatic tissue in the animal body and to correlate the normal age changes in the thymus and lymph nodes with the growth of other tissues and organs. A study of the normal growth of the lymph nodes and thymus was attempted in the rabbit by Hellman ('14), and to a lesser extent in the rat by Reinhardt ('46) and in the guinea pig by Gyllensten ('53). In recent years, the influences of the adrenocortical hormones and alarming stimuli upon the mass and cytology of lymphatic tissue in mice have been under extensive investigation (Dougherty, '52; Santisteban and Dougherty, '54; Santisteban and Swinyard, '56; Santisteban, '55, '56, '58, '59). In these studies the responses of the entire lympatic tissue to various experimental conditions have been assayed by sampling a few lymphatic organs and comparing them with the normal, using animals of the same age and sex. There is abundant evidence which indicates that the growth and involution of the thymus is also influenced by pituitary, thyroid and gonadal factors (Dougherty, '52; Shrewsbury and Reinhardt, '55). However, a complete analysis of the influences of age and sex upon the growth of lymphatic tissue in mice has never been reported. In the present study the influences of aging, sex and the adrenal glands upon the growth and involution of the thymus and representative lymph nodes have been studied. This has been done by correlating the alterations in the weights of the various types of lymphatic organs with each other and with respect to differences in age and sex as well as with respect to the general body growth and the growth of genital tissue and adrenal glands. The results presented here provided the basis for studies of the influences of aging and sex upon the growth of lymphatic tissue following adrenalectomy. The latter are being separately reported.