A microbial association with autism.
A microbial association with autism.
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作者：
Benach JL;Li E;McGovern MM
孤独症是一组复杂的发展障碍，导致许多可能的病因。存在与自闭症谱系障碍（ASD）相关的已知数量的合并症，通常包括胃肠道（GI）病理，其可以包括便秘、腹泻、腹痛、胃食管反流和呕吐的可变组合。美国儿科学会共识小组建议进行前瞻性研究，以确定ASD中GI疾病的患病率及其病理生理基础。在最近的一篇文章中，威廉姆斯等人[B. L.威廉姆斯，M. Hornig，T. Parekh和W. I. Lipkin，mBio 3（1）：e00261 - 11，2012]提供了一项这样的自闭症与GI共病的研究，其通过提供来自诊断为ASD的患者的回肠粘膜活检标本中的Sutterella属物种的证据，但在具有GI症状的对照儿童中没有，表明Sutterella在ASD中的特定作用。Sutterella序列占总细菌序列的约1 - 7%，这对自闭症表型的回肠粘膜组成的影响非常大，相当于或可能超过回肠克罗恩病表型的影响。这项研究开辟了一个新的研究领域，研究ASD中GI合并症的病因或后果。
Autism is a heterogeneous group of complex developmental disabilities that result from a number of possible etiologies. There are a well-known number of comorbidities associated with autism spectrum disorders (ASD), including, commonly, gastrointestinal (GI) pathology, which can include variable combinations of constipation, diarrhea, abdominal pain, gastroesophageal reflux, and vomiting. An American Academy of Pediatrics consensus panel has recommended that prospective studies be carried out to determine the prevalence of GI disorders in ASD and their pathophysiologic basis. In a recent article, Williams et al. [B. L. Williams, M. Hornig, T. Parekh, and W. I. Lipkin, mBio 3(1):e00261-11, 2012] have provided one such study of autism with GI comorbidities by presenting evidence of Sutterella species in ileal mucosal biopsy specimens from patients diagnosed with ASD but not in control children with GI symptoms, suggesting a specific role for Sutterella in ASD. Sutterella sequences represented ~1 to 7% of the total bacterial sequences, and this is a very large effect size on the ileal mucosal composition of the autism phenotype, rivaling or perhaps exceeding the effect size of the ileal Crohn’s disease phenotype. This study opens a new field of investigation to study the etiology or consequences of GI comorbidities in ASD.