An image-based approach for designing and manufacturing craniofacial scaffolds
An image-based approach for designing and manufacturing craniofacial scaffolds
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DOI：
10.1034/j.1399-0020.2000.290115.x
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发表时间：
2000-02-01
影响因子：
2.4
通讯作者：
Feinberg, SE
中科院分区：
文献类型：
--
作者：
Hollister, SJ;Levy, RA;Feinberg, SE
骨组织工程（BTE）将生物材料支架与生物活性因子相结合，为重建颅面缺损带来了巨大的前景。颅面重建 BTE 应用中的一个重大挑战是必须重建复杂的患者特定几何形状。在本文中，我们提出了一种基于图像的方法，用于直接根据 CT 或 MRI 数据设计和制造患者特异性颅面生物材料支架。在这种方法中，体素密度分布用于定义支架拓扑。脚手架设计拓扑是使用图像处理技术创建的，然后将该体素密度分布转换为可用于驱动固体自由形状制造机器直接构建脚手架或为脚手架构建模具的数据。阐述了颅面手术的几种初步应用，包括下颌骨髁支架、眼眶底支架和一般下颌缺损支架。最后，我们展示了在体内模型中的应用。
Bone tissue engineering (BTE), which combines biomaterial scaffolds with biologically active factors, holds tremendous promise for reconstructing craniofacial defects. A significant challenge in craniofacial reconstructive BTE applications is the complex patient-specific geometry that must be reconstructed. In this paper, we present an image-based approach for designing and manufacturing patient-specific craniofacial biomaterial scaffolds directly from CT or MRI data. In this approach, voxel density distribution is used to define scaffold topology. The scaffold design topology is created using image processing techniques, This voxel density distribution is then converted to data that can be used to drive a Solid Free-Form Fabrication machine to either directly build the scaffold or build a mold for the scaffold. Several preliminary applications for craniofacial surgery including a mandibular condyle scaffold, an orbital floor scaffold, and a general mandibular defect scaffold, are illustrated. Finally, we show applications to in vivo models.