Artificial control of swimming in goldfish by brain stimulation: Confirmation of the midbrain nuclei as the swimming center
Artificial control of swimming in goldfish by brain stimulation: Confirmation of the midbrain nuclei as the swimming center
复制标题
DOI：
10.1016/j.neulet.2009.01.035
复制
发表时间：
2009-03-06
影响因子：
2.5
通讯作者：
Uematsu, Kazumasa
中科院分区：
文献类型：
--
作者：
Kobayashi, Nobutaka;Yoshida, Masayuki;Uematsu, Kazumasa
电刺激自由运动金鱼的中脑运动区，包括内侧纵束核（Nflm）。刺激中线上的位点引起向前运动，而刺激中线外的位点引起转向刺激侧。刺激部位越接近Nflm，引起自发运动所需的阈值刺激强度越低。使用无线控制的双通道微刺激器，金鱼在水平面上的运动可以直接通过刺激Nflm来控制涉及躯干和尾巴的运动。在装有刺激装置和植入左右Nflm中或附近的电极的金鱼中，可以任意诱导向前和转向运动。与以前的观察一起，这些发现证实了Nflm在驱动脊髓节段性节律发生器启动游泳中的作用，这涉及躯干肌肉组织的节律性收缩。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
The midbrain locomotor region including the nucleus of the medial longitudinal fasciculus (Nflm) was electrically stimulated in free-moving goldfish. Stimulation of sites on the midline induced forward movement, whereas that of sites off midline induced turning toward the stimulated side. The closer the site of stimulation to Nflm, the lower the threshold stimulus intensity required to evoke locomotor movement. Using a wirelessly controlled two-channel microstimulator, the locomotion of goldfish in the horizontal plane could be controlled directly by stimulating Nflm for movements involving the trunk and tail. Forward and turning movements could be arbitrarily induced in goldfish equipped with the stimulation device and electrodes implanted in or near the right and left Nflm. Together with previous observations, these findings confirm the role of Nflm in driving spinal segmental rhythm generators initiating swimming, which involves rhythmic contractions of the trunk musculature. (C) 2009 Elsevier Ireland Ltd. All rights reserved.