Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach
Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach
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DOI：
10.1016/j.mad.2013.12.004
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发表时间：
2014-03-01
影响因子：
5.3
通讯作者：
De Vos, Willem M.
中科院分区：
文献类型：
--
作者：
Candela, Marco;Biagi, Elena;De Vos, Willem M.
肠道微生物群与宿主共享强烈的转基因代谢，是人体生理学几个方面的重要因素。然而，一些与年龄相关的因素，如饮食，生活方式，炎症和虚弱的变化，迫使这种肠道微生物-宿主互惠互动的恶化，损害了达到长寿的可能性。在这种情况下，NU-AGE项目涉及开发专门针对维持肠道微生物组健康轨迹的饮食干预措施，抵消与人类衰老病理生理学相关的所有过程。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Sharing an intense transgenomic metabolism with the host, the intestinal microbiota is an essential factor for several aspects of the human physiology. However, several age-related factors, such as changes diet, lifestyle, inflammation and frailty, force the deterioration of this intestinal microbiota-host mutualistic interaction, compromising the possibility to reach longevity. In this scenario, the NU-AGE project involves the development of dietary interventions specifically tailored to the maintenance of a healthy trajectory of the intestinal microbiome, counteracting all processes connected to the pathophysiology of the human aging. (C) 2014 Elsevier Ireland Ltd. All rights reserved.