A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition
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DOI：
10.1176/appi.ajp.159.4.652
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发表时间：
2002-04-01
影响因子：
17.7
通讯作者：
Goldman, D
中科院分区：
文献类型：
--
作者：
Malhotra, AK;Kestler, LJ;Goldman, D
目的：在前额叶皮层，儿茶酚O-甲基转移酶（COMT）在多巴胺的代谢降解中至关重要，多巴胺是一种假设影响人类认知功能的神经递质。COMT基因包含一个功能多态性，Val 158 Met，对酶活性产生四倍的影响。本研究旨在探讨COMT基因型对前额叶认知功能的影响。一个任务的前额叶认知，威斯康星州卡片分类Test.Results的主题，只有低活性的Met等位基因的威斯康星州卡片分类Test.Conclusions的主题比瓦尔等位基因的持续错误显着减少：这些数据与以前的研究是一致的，表明功能性遗传多态性可能会影响前额叶认知。
Objective: In the prefrontal cortex, the enzyme catechol O-methyltransferase (COMT) is critical in the metabolic degradation of dopamine, a neurotransmitter hypothesized to influence human cognitive function. The COMT gene contains a functional polymorphism, Val158Met, that exerts a fourfold effect on enzyme activity. The current study investigated whether prefrontal cognition varies with COMT genotype.Method: Val158Met was genotyped in 73 healthy volunteers. A task of prefrontal cognition, the Wisconsin Card Sorting Test, was also administered.Results: Subjects with only the low-activity met allele made Significantly fewer perseverative errors on the Wisconsin Card Sorting Test than did subjects with the val allele.Conclusions: These data are consistent with those of previous studies, suggesting that a functional genetic polymorphism may influence prefrontal cognition.