METABOLISM OF SOME NATURALLY-OCCURRING ISOTHIOCYANATES IN THE RAT
METABOLISM OF SOME NATURALLY-OCCURRING ISOTHIOCYANATES IN THE RAT
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DOI：
10.3109/00498258309052256
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发表时间：
1983-01-01
期刊：
影响因子：
1.8
通讯作者：
KRUMBIEGEL, G
中科院分区：
文献类型：
--
作者：
MENNICKE, WH;GORLER, K;KRUMBIEGEL, G
The metabolism of methyl, ethyl, butyl and allyl isothiocyanate, which occur as glucosinolates in a number of plants, was studied. Oral administration of the substances to the rat was followed by their renal excretion as mercapturic acids, which were isolated as dicyclohexylamine salts. Chemical structure was determined by synthesis and 1H-NMR spectra. The mercapturic acids were very labile dithiocarbamidic acid esters, formed by the addition of the isothiocyanate group to the SH group of the cysteine component.
