Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats.
Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats.
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DOI：
10.1152/ajpregu.1997.273.2.r833
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发表时间：
1997-08
期刊：
影响因子：
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通讯作者：
Yang Wang;Y. Taché;A. B. Sheibel;Vay Liang W. Go;J. Wei
中科院分区：
文献类型：
--
作者：
Yang Wang;Y. Taché;A. B. Sheibel;Vay Liang W. Go;J. Wei
In vitro gastric vagal afferents' (GVAs) unit activities were recorded from the ventral GVA nerve strands in rats. The responsiveness of 16 GVA terminals to close intra-arterial injection of vehicle (0.1 ml), leptin (350 pmol), and cholecystokinin (CCK)-8 (10 pmol) was analyzed to generate a spike count-versus-time histogram. Data of 5-min spike counts before and after each treatment were normalized by dividing the latter by the former. A quotient (Q) > 1 indicates an excitatory effect, Q 1; CCK-8 pretreatment did not consistently alter leptin sensitivity. In contrast, Type 2 (n = 8) responded to leptin with Q 1. These data suggest that Type 1 and Type 2 GVA terminals may provide afferent neural signals, which, in turn, will be involved in body weight and food intake control systems, respectively.
