EFFECTS OF BOTULINUM TOXIN ON PATTERN OF INNERVATION OF SKELETAL MUSCLE IN MOUSE
EFFECTS OF BOTULINUM TOXIN ON PATTERN OF INNERVATION OF SKELETAL MUSCLE IN MOUSE
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DOI：
10.1113/expphysiol.1968.sp001948
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发表时间：
1968-01-01
影响因子：
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通讯作者：
STRICH, SJ
中科院分区：
文献类型：
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作者：
DUCHEN, LW;STRICH, SJ
将亚致死量的肉毒杆菌毒素注射到小鼠一条腿的腓肠肌和腘绳肌中。局部麻痹和萎缩发生并持续数周。组织学检查显示神经纤维或运动神经末梢无变性。银染显示，在肌肉麻痹期间，有运动神经纤维从终末分支生长。神经纤维的过度生长伴随着胆碱酯酶活性位点的伸长和异常配置。随着肌肉功能的恢复，神经纤维过度生长逐渐消退，并且可以看到形态良好但仍然形状异常的神经下装置。注射毒素9个月后，肌肉的神经支配模式仍然异常。注射肉毒杆菌毒素后运动神经纤维的生长似乎是对神经肌肉传递失败的反应，而不是类似于创伤后神经纤维的再生。
Sublethal quantities of botulinum toxin were injected into the gastrocnemius and hamstring muscles of one leg in mice. Local paralysis and atrophy occurred and persisted for a few weeks. Histological examination showed no degeneration of nerve fibers or of motor nerve endings. Silver impregnations showed that during the period of muscle paralysis there was growth of motor nerve fibers from the terminal arborizations. Nerve fiber overgrowth was accompanied by elongation and abnormal configuration of sites of cholinesterase activity. As muscle function recovered the nerve fiber overgrowth receded and well-formed though still abnormally shaped subneural apparatuses were seen. Nine months after the injection of the toxin, the pattern of innervation of the muscle was still abnormal. The growth of motor nerve fibers after the injection of botulinum toxin appears to be a response to the failure of neuromuscular transmission and is not analogous to regeneration of nerve fibers after trauma.