DEFECTIVE RETICULOENDOTHELIAL SYSTEM FC-RECEPTOR FUNCTION IN SYSTEMIC LUPUS-ERYTHEMATOSUS
DEFECTIVE RETICULOENDOTHELIAL SYSTEM FC-RECEPTOR FUNCTION IN SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1056/nejm197903083001002
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
PLOTZ, PH
中科院分区：
文献类型：
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作者：
FRANK, MM;HAMBURGER, MI;PLOTZ, PH
为确定系统性红斑狼疮患者网状内皮系统网状内皮系统特异性Fc受体功能是否异常，对15例未经治疗的患者进行了免疫球蛋白G致敏、51Cr标记的红细胞清除功能的研究。15例患者中有13例Fc特异性清除率显著异常(80-2256min，P<；与对照组相比减半0.001)。异常清除与免疫复合体水平(通过C1q[补体成分1的Q片段]结合试验测量)和疾病活动性相关。C1q结合活性和抗DNA滴度与疾病活动性相关。C3、C4、CH50[总溶血C]和B因子与异常清除和疾病活动性的相关性较弱或不存在。清除率、疾病活动性和C1q结合活性之间的显著相关性提示，Fc受体功能缺陷可能导致免疫复合物循环时间延长，从而导致组织沉积和损伤。
To determine whether reticuloendothelial-system RES immunospecific Fc-receptor function is abnormal in patients with systemic lupus erythematosus, the clearance of Ig[immunoglobulin]G-sensitized, 51Cr-labeled erythrocytes by these splenic macrophage membrane receptors was studied in 15 untreated patients. Fc-specific clearance rates were strikingly abnormal in 13 of 15 patients (half-times ranging 80-2256 min, P < 0.001 as compared to controls). Abnormal clearances correlated with immune complex levels (as measured by the C1q[q fragment of complement component 1]-binding assay) and with disease activity. C1q-binding activity and anti-DNA titers correlated with disease activity. The correlations of C3, C4, CH50 [total hemolytic C] and factor B with abnormal clearance and disease activity were weaker or nonexistent. The significant correlations among clearance, disease activity and C1q-binding activity suggest that the defect in Fc-receptor function may lead to the prolonged circulation of immune complexes, thereby contributing to tissue deposition and damage.