Regulation of IL-4 Expression in Immunity and Diseases
Regulation of IL-4 Expression in Immunity and Diseases
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DOI：
10.1007/978-94-024-0921-5_3
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Miaw, Shi-Chuen
中科院分区：
文献类型：
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作者：
Ho, I-Cheng;Miaw, Shi-Chuen
IL-4 was first identified as a T cell-derived growth factor for B cells. Studies over the past several decades have markedly expanded our understanding of its cellular sources and function. In addition to T cells, IL-4 is produced by innate lymphocytes, such as NTK cells, and myeloid cells, such as basophils and mast cells. It is a signature cytokine of type 2 immune response but also has a nonimmune function. Its expression is tightly regulated at several levels, including signaling pathways, transcription factors, epigenetic modifications, microRNA, and long non coding RNA. This chapter will review in detail the molecular mechanism regulating the cell type-specific expression of IL-4 in physiological and pathological type 2 immune responses.
