Glutathione S transferase deficiency and passive smoking increase childhood asthma
Glutathione S transferase deficiency and passive smoking increase childhood asthma
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DOI：
10.1136/thx.2003.016667
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发表时间：
2004-07-01
期刊：
影响因子：
10
通讯作者：
von Mutius, E
中科院分区：
文献类型：
--
作者：
Kabesch, M;Hoefler, C;von Mutius, E
背景资料：有人建议，基因决定的缺乏谷胱甘肽S转移酶（GST）酶参与环境烟草烟雾（ETS）成分的解毒可能有助于发展asthma.Methods：一个大的人口德国学龄儿童（n = 3054）基因型缺陷的GST亚型M1和T1。GSTM 1和GSTT 1基因型与哮喘以及特应性之间的关联通过当前和子宫内ETS暴露进行了研究。在缺乏GSTM 1等位基因的儿童中，暴露于当前ETS的儿童中，（OR 5.5，95% CI 1.6 - 18.6）和哮喘症状，如喘息（OR 2.8，95%CI 1.3 ~ 6.0）、当前喘息（OR 4.7，95%CI 1.8 ~ 12.6）和呼吸短促（OR 8.9，95%CI 2.1 ~ 38.4）的发生率高于未暴露于ETS的GSTM 1阳性个体。ETS暴露和GSTM 1缺乏之间的相互作用的提示被确定。在子宫内吸烟暴露在GSTT 1缺陷的儿童与肺功能显着下降相比，GSTT 1阳性的儿童没有暴露于ETS。结论：GSTM 1和GSTT 1缺陷可能会增加不良健康影响的子宫内和当前的烟雾暴露。
Background: It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma.Methods: A large population of German schoolchildren (n = 3054) was genotyped for deficiencies of the GST isoforms M1 and T1. The association between GSTM1 and GSTT1 genotypes and asthma as well as atopy was investigated with respect to current and in utero ETS exposure.Results: In children lacking the GSTM1 allele who were exposed to current ETS the risk for current asthma (OR 5.5, 95% CI 1.6 to 18.6) and asthma symptoms such as wheeze ever (OR 2.8, 95% CI 1.3 to 6.0), current wheezing (OR 4.7, 95% CI 1.8 to 12.6) and shortness of breath (OR 8.9, 95% CI 2.1 to 38.4) was higher than in GSTM1 positive individuals without ETS exposure. Hints of an interaction between ETS exposure and GSTM1 deficiency were identified. In utero smoke exposure in GSTT1 deficient children was associated with significant decrements in lung function compared with GSTT1 positive children not exposed to ETS.Conclusions: GSTM1 and GSTT1 deficiency may increase the adverse health effects of in utero and current smoke exposure.