Isoflavonoids and chronic disease: Mechanisms of action
Isoflavonoids and chronic disease: Mechanisms of action
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DOI：
10.1002/biof.5520120133
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发表时间：
2000-01-01
期刊：
影响因子：
6
通讯作者：
Xu, J
中科院分区：
文献类型：
--
作者：
Barnes, S;Boersma, B;Xu, J
大豆和它的黄酮类化合物与降低慢性疾病的风险有关。雌甾酮的作用机制包括其作为弱雌激素的作用。酪氨酸激酶依赖性信号转导过程的抑制剂和细胞抗氧化剂。虽然雌激素受体β结合染料木黄酮的亲和力接近于17 β-雌二醇，但它是否是染料木黄酮体内活性的介体仍有待确定。染料木黄酮对蛋白酪氨酸激酶的抑制作用并不局限于直接作用于这些激酶，而是可能通过改变激酶的表达而产生。染料木黄酮不是一种特别好的细胞氧化剂清除剂;然而，它与促氧化剂次氯酸发生强烈反应，次氯酸由中性粒细胞产生，作为炎症反应的一部分。与其母体化合物相比，氯代异黄酮可能具有改变的生物化学和生物学效应，并可能提供增强的抗炎性疾病保护。
Soy and its isoflavones are associated with a reduced risk of chronic disease. The mechanisms of action of isoflavones include their roles as weak estrogens. inhibitors of tyrosine kinase-dependent signal transduction processes and as cellular antioxidants. Although estrogen receptor beta binds genistein with an affinity close to that of 17 beta -estradiol, it remains to be determined whether it is a mediator of genistein's activity in vivo. Genistein's inhibition of protein tyrosine kinases is not limited to direct effect on these kinases, but may result from alteration in kinase expression. Genistein is not a particularly good scavanger of cellular oxidants; however, it reacts vigorously with the prooxidant hypochlorous acid, produced by neutrophils as part of the inflammatory response. The chlorinated isoflavones may have altered biochemical and biological effects compared to their parent compounds and may provide increased protection against inflammatory disease.