Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons
Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons
复制标题
DOI：
10.1007/s00198-013-2568-2
复制
发表时间：
2014-03-01
影响因子：
4
通讯作者：
Johnston, J. D.
中科院分区：
文献类型：
--
作者：
Burnett, W. D.;Kontulainen, S. A.;Johnston, J. D.
基于CT的深度特异性图像处理能够准确地识别健康和骨关节炎患者之间的区域差异。本研究旨在利用基于CT的密度分析来评估正常人和骨关节炎(OA)患者体内局部特定深度软骨下骨密度(BMD)的精度误差和潜在差异。14名参与者(2名男性和12名女性；平均年龄51.4岁；SD，11.8岁)在2天内接受了3次临床定量CT(QCT)扫描。参与者被分为正常组(n=7)和表现为放射性骨性关节炎组(n=7)。在相对于软骨下表面的三个深度上评估平均软骨下骨密度。区域骨密度分析包括：距软骨下表面0~2.5 mm、2.5~5 mm、5~7.5 mm归一化深度的外、内侧小关节总BMD、总内侧小关节骨密度、上、中、下小关节骨密度。我们使用均方根变异系数(CV%)来评估精密度。我们通过(1)计算两组之间的百分比差异(相对于正常BMD)，(2)将百分比差异与各自的CV%误差联系起来，以及(3)使用Cohen‘s来确定效应大小，来评估OA和正常BMD之间的差异。骨密度与正常骨密度的百分比差值为-1.6%~-30.1%(骨密度低于正常骨密度)。在精度误差方面，百分比差异平均比CV%误差大5.5倍。科恩的d效应大小在-1.7到-0.1之间。最大的差异出现在距软骨下表面2.5-5 mm和5-7.5 mm的深度。髌骨软骨下骨密度测量是精确的(平均变异系数%，百分之一货币符号3%)。这一基于区域和深度的CT成像工具描述了活体正常和骨关节炎患者的局部标准化骨密度差异。
Computed tomography-based depth-specific image processing is able to precisely identify regional differences between healthy patellae and patellae with osteoarthritis.This study aims to assess the precision errors and potential differences in regional, depth-specific subchondral bone mineral density (BMD) in normal and osteoarthritic (OA) human patellae in vivo using CT-based density analyses.Fourteen participants (2 men and 12 women; mean age, 51.4; SD, 11.8 years) were scanned using clinical quantitative CT (QCT) three times over 2 days. Participants were categorized as either normal (n = 7) or exhibiting radiographic OA (n = 7). Average subchondral BMD was assessed at three depths relative to the subchondral surface. Regional BMD analysis included: total lateral facet BMD, total medial facet BMD, and superior/middle/inferior BMD of lateral and medial facets at normalized depths of 0-2.5, 2.5-5, and 5-7.5 mm from the subchondral surface. We assessed precision using root mean square coefficients of variation (CV%). We evaluated differences between OA and normal BMD by (1) calculating percentage differences between the groups (in relation to normal BMD) (2) relating percentage differences to respective CV% errors and (3) determining effect sizes using Cohen's d.Root mean square CV% precision errors ranged from 1.1 to 5.9 %. Percentage differences between OA and normal BMD varied from -1.6 to -30.1 % (BMD lower in OA patellae). In relation to precision errors, percentage differences were, on average, 5.5x greater than CV% errors. Cohen's d effect sizes ranged from -1.7 to -0.1. Largest differences were noted at depths of 2.5-5 and 5-7.5 mm from the subchondral surface.Patellar subchondral BMD measures were precise (average CV%, a parts per thousand currency sign3 %). This region- and depth-specific CT-based imaging tool characterized regional standardized BMD differences between normal and OA patellae in vivo.