Life course epidemiology of trauma and related psychopathology in civilian populations.

Life course epidemiology of trauma and related psychopathology in civilian populations.
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DOI:
10.1007/s11920-015-0566-0
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发表时间:
2015-05
影响因子:
6.7
通讯作者:
Galea, Sandro
Galea, Sandro
中科院分区:
医学2区
文献类型:
--
作者:
Fink, David S.;Galea, Sandro

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创伤事件是无处不在的暴露,与生活过程事件相互作用,增加急性精神病理的风险,改变心理健康轨迹。虽然大多数遭受创伤的人经历了轻微到中度的心理痛苦,然后恢复到创伤前的健康,但许多遭受创伤的人经历了持续数年的严重痛苦。因此,为了努力理解为什么暴露在创伤中会引发如此广泛的反应,我们采用了一种生命历程方法,该方法考虑了从社会因素到生物因素的生活经历的复杂积累和相互作用,这些经历发生在一生中--从怀孕到死亡,并跨越几代人。我们将这一证据分为三类:遗传学和生物学、个人暴露和社区体验,然后讨论现有研究中的挑战和未来研究的方向。
Traumatic events are ubiquitous exposures that interact with life course events to increase risk of acute psychopathology and alter mental health trajectories. While the majority of persons exposed to trauma experience mild to moderate psychological distress followed by a return to pre-trauma health, many persons exposed to trauma experience substantial distress that lasts for several years. Therefore, in an effort to understand why exposure to trauma can provoke such a range of reactions, we apply a life course approach that considers the complex accumulation and interaction of life experiences that range from social to biological factors, which occur over the life span—from gestation to death and across generations. We present this evidence in three categories: genetics and biology, individual exposures, and community experiences, followed by discussing challenges in existing research, and directions for future study.
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