Effect of dietary rare earth elements on growth performance and blood parameters of rats
Effect of dietary rare earth elements on growth performance and blood parameters of rats
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DOI：
10.1046/j.1439-0396.2003.00432.x
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发表时间：
2003-06-01
影响因子：
2.7
通讯作者：
Rambeck, WA
中科院分区：
文献类型：
--
作者：
He, ML;Wang, YZ;Rambeck, WA
稀土元素（REE）已被证明影响动物生产中的生长性能，特别是在猪中。本文研究了口服稀土元素对生长期大鼠的影响。纯氯化镧或稀土混合物含有38%的氯化镧，52%的氯化铈，3%的氯化镨和7%的氯化物的其他稀土，在两个不同的浓度作为补充的饮食。将50只4周龄雄性Wistar大鼠分为5个实验组：对照组、低镧组和高镧组（分别给予75和150 mg/kg LaCl 3·6 H（2）O）、低稀土组和高稀土组（分别给予75和150 mg/kg REE混合物）。将动物圈养在单独的畜栏中。自由采食饲料和饮水。18天后，口服补充LaCl 3.6H（2）O或REE混合物分别使日增重提高5%或9%（p > 0.05）。LaCl_3.6H（2）O和稀土混合物对饲料转化率（FCR）有显著影响（p < 0.05），分别降低了8%和11%。补充稀土元素对血清指标也有明显影响。碱性磷酸酶（AP）和丙氨酸氨基转移酶（ALT）活性显著升高（p < 0.05）。同时，血糖水平显著降低，血肌酸水平显著升高（P < 0.05）。胆固醇、总蛋白、白蛋白、尿素氮各组间差异无统计学意义。对照组与稀土组之间甘油三酯水平差异不显著，但150 mg/kg稀土混合物组甘油三酯水平显著低于75 mg/kg稀土混合物组和150 mg/kg氯化镧组（p < 0.01）。结果表明，口服补充稀土改善生长性能的大鼠在猪。在这方面，添加到日粮中的稀土的浓度和类型是两个重要的因素。
Rare earth elements (REE) have been shown to influence growth performance in animal production, especially in pigs. In the present study, the effect of oral administration of rare earth elements on growing rats was investigated. Pure LaCl3 or an REE mixture containing 38% of LaCl3 , 52% of CeCl3 , 3% of PrCl3 and 7% of chlorides of other REE were used at two different concentrations as supplements to the diets. Fifty male Wistar rats at 4 weeks of age were allotted to five experimental groups: a control group; a La-low group and a La-high group with 75 and 150 mg/kg LaCl3 .6H(2) O, respectively; a REE-low and an REE-high group with 75 and 150 mg/kg REE mixture, respectively. The animals were housed in individual pens. Feed and water were provided ad libitum . After 18 days the oral supplementation of LaCl3 .6H(2) O or of the REE mixture improved daily body weight gain (BWG) by up to 5 or 9% (p > 0.05), respectively. LaCl3 .6H(2) O as well as the REE mixture had positive effects (p < 0.05) on feed conversion ratio (FCR) with a decreased ratio by up to 8 and 11%, respectively. Supplementation of REE also had clear effects on blood serum parameters. The activities of alkaline phosphatase (AP) and alanine amino transferase (ALT) increased significantly (p < 0.05). At the same time, blood glucose level decreased and blood creatine level increased significantly (p < 0.05). There was no significant difference in cholesterol, total protein, albumin and urea nitrogen among the groups. There was no significant difference in triglyceride level between the control and those REE groups, however, a significantly lower (p < 0.01) triglyceride level was found in the 150 mg/kg REE mixture group compared with that in 75 mg/kg REE mixture group and the 150 mg/kg LaCl3 .6H(2) O group. The results suggest that oral supplementation of REE improves growth performance in rats as in pigs. In this respect, concentration and type of REE supplemented to the diets are two important factors herein.