Tailored Additives for Incorporation of Antibacterial Functionality Into Laser Sintered Parts
Tailored Additives for Incorporation of Antibacterial Functionality Into Laser Sintered Parts
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DOI：
10.3389/fbiom.2022.929006
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发表时间：
2022-07
期刊：
影响因子：
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通讯作者：
J. R. Wingham;I. Ahmed;M. Islam;J. Shepherd;C. Majewski
中科院分区：
文献类型：
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作者：
J. R. Wingham;I. Ahmed;M. Islam;J. Shepherd;C. Majewski
传染病是世界范围内造成死亡的主要原因，因此对能够控制疾病传播的新方法的需求很大。本研究提出了一种生产抗菌微复合材料的方法，利用激光烧结增材制造工艺的粉末性质，通过加入含银添加剂。设计不同配方的磷酸银玻璃添加剂，考察其溶出度对抗菌效果的影响。在不影响机械性能的情况下，将这些特性成功地纳入聚酰胺12部件中。在营养不良的条件下，打印的微复合材料对革兰氏阳性和革兰氏阴性细菌均具有抗菌和抗菌效果，其效果对银含量的敏感性高于降解率。
Infectious disease is a major cause of death worldwide, and novel methods capable of controlling the spread of disease are in high demand. This research presents a method of producing antimicrobial microcomposites by exploiting the powder-based nature of the Laser Sintering Additive Manufacturing process, via the incorporation of silver-containing additives. Silver phosphate glass additives in different formulations were designed to determine the effect of dissolution rate on the antimicrobial efficacy. These were characterised and successfully incorporated into polyamide 12 parts, without affecting the mechanical properties. The printed microcomposite parts displayed both bactericidal and antibiofouling effects against Gram-positive and Gram-negative bacteria in nutrient-poor conditions, with the efficacy found to be more sensitive to silver content than degradation rate.