Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices
Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices
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DOI：
10.1021/la0480336
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发表时间：
2004-11-09
期刊：
影响因子：
3.9
通讯作者：
Higuchi, T
中科院分区：
文献类型：
--
作者：
Okushima, S;Nisisako, T;Higuchi, T
一种具有疏水和亲水组分的微流体装置，用于生产多相乳剂。为了产生油包水（W/(O) / bar /W）分散，在上游疏水结处破裂的水滴被包裹在下游亲水结处形成的有机液滴中。在每个结处产生的液滴可以具有狭窄的尺寸分布，直径变化系数小于3%。流动条件的控制会产生内部/外部液滴大小和内部液滴数量的变化。通过改变微通道的几何形状和润湿性，制备了W/O/W乳液（内部有两种类型的液滴）和油包水包油乳液。
A microfluidic device having both hydrophobic and hydrophilic components is exploited for production of multiple-phase emulsions. For producing water-in-oil-in-water (W/(O) over bar /W) dispersions, aqueous droplets ruptured at the upstream hydrophobic junction are enclosed within organic droplets formed at the downstream hydrophilic junction. Droplets produced at each junction could have narrow size distributions with coefficients of variation in diameter of less than 3%. Control of the flow conditions produces variations in internal/external droplet sizes and in the internal droplet number. Both W/O/W emulsions (with two types of internal droplets) and oil-in-water-in-oil emulsions were prepared by varying geometry and wettability in microchannels.