N-Acetylcysteine Combined With Dexamethasone Treatment Improves Sudden Sensorineural Hearing Loss and Attenuates Hair Cell Death Caused by ROS Stress.
N-Acetylcysteine Combined With Dexamethasone Treatment Improves Sudden Sensorineural Hearing Loss and Attenuates Hair Cell Death Caused by ROS Stress.
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N-乙酰半胱氨酸联合地塞米松治疗可改善突发感音神经性听力损失并减轻 ROS 应激引起的毛细胞死亡
DOI：
10.3389/fcell.2021.659486
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发表时间：
2021
影响因子：
5.5
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Bai X;Chen S;Xu K;Jin Y;Niu X;Xie L;Qiu Y;Liu XZ;Sun Y
突发性感音神经性耳聋（SSNHL）是世界上常见的急症。越来越多的证据表明，氧化-抗氧化失衡的SSNHL患者。类固醇联合抗氧化剂可能是治疗SSNHL的潜在策略。在耳蜗外植实验中，我们发现N-乙酰半胱氨酸（NAC）与地塞米松联合应用，在两者单独使用时，均能有效地保护耳蜗毛细胞免受氧化应激的损伤。目的：探讨口服NAC联合鼓室内注射地塞米松（ITD）作为挽救治疗是否有更好的疗效。41例SSNHL患者随机分为两组。对照组23例仅接受ITD治疗，NAC组18例在此基础上口服NAC。在第1天（治疗开始）和第14天对患者进行随访。总体而言，两组之间的最终纯音听阈平均值（PTA）改善无统计学差异。然而，NAC组在8，000 Hz处观察到显著的听力增益。NAC组听力恢复率明显高于对照组。这些结果表明，口服NAC联合ITD治疗比单独ITD治疗更有效。
Sudden sensorineural hearing loss (SSNHL) is a common emergency in the world. Increasing evidence of imbalance of oxidant–antioxidant were found in SSNHL patients. Steroids combined with antioxidants may be a potential strategy for the treatment of SSNHL. In cochlear explant experiment, we found that N-acetylcysteine (NAC) combined with dexamethasone can effectively protect hair cells from oxidative stress when they were both at ineffective concentrations alone. A clinic trial was designed to explore whether oral NAC combined with intratympanic dexamethasone (ITD) as a salvage treatment has a better therapeutic effect. 41 patients with SSNHL were randomized to two groups. 23 patients in control group received ITD therapy alone, while 18 patient s in NAC group were treated with oral NAC and ITD. The patients were followed-up on day 1st (initiation of treatment) and day 14th. Overall, there was no statistical difference in final pure-tone threshold average (PTA) improvement between those two groups. However, a significant hearing gain at 8,000 Hz was observed in NAC group. Moreover, the hearing recovery rates of NAC group is much higher than that in control group. These results demonstrated that oral NAC in combination with ITD therapy is a more effective therapy for SSNHL than ITD alone.
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影响因子：
9
作者：
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