Monocarboxylate transporters in breast cancer and adipose tissue are novel biomarkers and potential therapeutic targets
Monocarboxylate transporters in breast cancer and adipose tissue are novel biomarkers and potential therapeutic targets
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乳腺癌和脂肪组织中的单羧酸转运蛋白是新型生物标志物和潜在的治疗靶点
DOI：
10.1016/j.bbrc.2018.05.091
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发表时间：
2018-07-02
影响因子：
3.1
通讯作者：
Sun, Shengrong
中科院分区：
文献类型：
--
作者：
Li, Zhiyu;Wu, Qi;Sun, Shengrong
单羧酸转运蛋白（MCT）是控制乳酸代谢的跨膜蛋白，与包括乳腺癌（BC）在内的实体瘤的不良预后相关。本研究旨在评价免疫组织化学和基于量子点的荧光成像技术在BC和周围间质中使用MCT的临床和预后价值，重点是肿瘤和间质之间的相互作用。此外，从癌症基因组图谱（TCGA）的数据进行了分析，以评估乳腺癌患者中的MCT mRNA表达和预后之间的关系。我们的研究发现，MCTI过表达在激素受体阴性和高增殖亚型中观察到。肿瘤组织中MC 1和MCT 4的高表达与患者预后不良相关;此外，当与邻近脂肪组织中MCT 4过表达相结合时，乳腺癌中MCT 1表达与预后不良之间的相关性进一步加强。这些结果表明，MCT往往通过乳腺癌细胞和脂肪细胞之间的动态相互作用在侵袭性BC亚型中发挥作用，开发阻断这种相互作用的治疗方法将是癌症治疗中有前途的策略。(C)2018爱思唯尔公司All rights reserved.
Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate metabolism and associated with poor prognosis in solid tumours including breast cancer (BC). This study aimed to evaluate the clinical and prognostic value of MCTs used by immunohistochemistry and quantum dots based fluorescent imaging technique in BC and surrounding stroma with emphasis on the interaction between tumour and stroma. Moreover, the data from The Cancer Genome Atlas (TCGA) was analyzed to evaluate the association between MCTs mRNA expression and prognosis of breast cancer patients. Our study found that MCTI overexpression was observed in hormone receptor-negative and high proliferation subtypes. High expression of MC1 and MCT4 in tumour tissues was associated with poor patient outcome; further the correlation between MCT1 expression and poor prognosis in breast cancer was further strengthened when combined with MCT4 overexpression in the adjacent adipose tissue. These results demonstrate that MCTs tend to play a role in the aggressive BC subtypes through the dynamic interaction between breast cancer cells and adipocytes, and developing therapeutics to block this interaction will be a promising strategy in cancer therapy. (C) 2018 Elsevier Inc. All rights reserved.