Pretreatment with L-histidine produces a shift from methamphetamine-induced stereotypical biting to persistent locomotion in mice
Pretreatment with L-histidine produces a shift from methamphetamine-induced stereotypical biting to persistent locomotion in mice
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DOI：
10.1016/j.pbb.2009.10.009
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Takemura, Motohiko
中科院分区：
文献类型：
--
作者：
Kitanaka, Junichi;Kitanaka, Nobue;Takemura, Motohiko
甲基苯丙胺（METH; 10 mg/kg，i. p.）对雄性ICR小鼠的诱导奇异行为，包括持续的运动和刻板行为，这些行为被分为四类：刻板的摇头，盘旋，嗅闻和咬。用L-组氨酸（750 mg/kg，i. p.）显著降低了由METH诱导的刻板的叮咬，并显著增加了持续的运动。同时给予吡拉明或酮替芬（脑穿透性组胺H（1）受体拮抗剂;各10 mg/kg，腹腔注射），但不通过给予非索非那定（一种不穿过血脑屏障的非镇静组胺H（1）受体拮抗剂; 20 mg/kg）、唑来替定（一种脑穿透性组胺H（2）受体拮抗剂：10 mg/kg）、硫代哌丁胺或氯苄丙酸（脑穿透性组胺H（3）受体拮抗剂;各10 mg/kg）。L-组氨酸处理可显著增加下丘脑组胺含量。这些数据表明，L-组氨酸通过中枢组胺H1受体改变METH的作用。(C)2009 Elsevier Inc. All rights reserved.
The administration of methamphetamine (METH; 10 mg/kg, i.p.) to male ICR mice induced bizarre behaviors including persistent locomotion and stereotypical behaviors, which were classified into four categories: stereotypical head-bobbing, circling, sniffing, and biting. Pretreatment with L-histidine (750 mg/kg, i.p.) significantly decreased the stereotypical biting induced by METH and significantly increased persistent locomotion. This effect of L-histidine on behavior was completely abolished by simultaneous administration of pyrilamine or ketotifen (brain-penetrating histamine H(1) receptor antagonists; 10 mg/kg each, i.p.), but not by the administration of fexofenadine (a non-sedating histamine H(1) receptor antagonist that does not cross the blood-brain barrier; 20 mg/kg), zolantidine (a brain-penetrating histamine H(2) receptor antagonist: 10 mg/kg), thioperamide, or clobenpropit (brain-penetrating histamine H(3) receptor antagonists; 10 mg/kg each). The histamine content of the hypothalamus was significantly increased by L-histidine treatment. These data suggest that L-histidine modifies the effects of METH through central histamine H, receptors. (C) 2009 Elsevier Inc. All rights reserved.