The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement.
The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement.
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DOI：
10.1016/j.neuron.2014.04.001
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发表时间：
2014-05-21
期刊：
影响因子：
16.2
通讯作者：
Kandler K
中科院分区：
文献类型：
--
作者：
Clause A;Kim G;Sonntag M;Weisz CJ;Vetter DE;Rűbsamen R;Kandler K
自发活动的模式是发展中的感觉系统的标志。在听觉系统中，自发活动的节律性爆发产生于耳蜗毛细胞中并沿沿着中枢听觉通路传播。这些活动模式在中枢听觉回路发育中的作用仍然是推测性的。在这里，我们证明了阻断烟碱乙酰胆碱受体α9亚基缺失小鼠（α9 KO小鼠）发育毛细胞的传出胆碱能神经传递改变了自发活动的时间精细结构，而不改变活动水平。KO小鼠表现出抑制性tonotopic地图的功能和结构锐化的严重损害，证明了在突触加强和沉默的连接和轴突修剪的情况下的赤字。这些结果提供的证据表明，在听力发作前的自发活动的精确的时间模式是至关重要的建立精确的tonotopy，主要的组织原则，中央听觉通路。
Patterned spontaneous activity is a hallmark of developing sensory systems. In the auditory system, rhythmic bursts of spontaneous activity are generated in cochlear hair cells and propagated along central auditory pathways. The role of these activity patterns in the development of central auditory circuits has remained speculative. Here we demonstrate that blocking efferent cholinergic neurotransmission to developing hair cells in mice that lack the α9 subunit of nicotinic acetylcholine receptors (α9 KO mice) altered the temporal fine-structure of spontaneous activity without changing activity levels. KO mice showed a severe impairment in the functional and structural sharpening of an inhibitory tonotopic map, as evidenced by deficits in synaptic strengthening and silencing of connections and an absence in axonal pruning. These results provide evidence that the precise temporal pattern of spontaneous activity before hearing onset is crucial for the establishment of precise tonotopy, the major organizing principle of central auditory pathways.
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影响因子：
2.5
作者：
HASHISAKI, GT;RUBEL, EW
通讯作者：
RUBEL, EW
影响因子：
25
作者：
Johnson, Stuart L.;Eckrich, Tobias;Kuhn, Stephanie;Zampini, Valeria;Franz, Christoph;Ranatunga, Kishani M.;Roberts, Terri P.;Masetto, Sergio;Knipper, Marlies;Kros, Corne J.;Marcotti, Walter
通讯作者：
Marcotti, Walter
影响因子：
5.3
作者：
Hanson, MG;Landmesser, LT
通讯作者：
Landmesser, LT
DOI：
10.1523/jneurosci.0803-12.2012
发表时间：
2012-08-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Johnson SL;Kennedy HJ;Holley MC;Fettiplace R;Marcotti W
通讯作者：
Marcotti W
DOI：
10.1007/s10162-008-0144-9
发表时间：
2009-03-01
影响因子：
2.4
作者：
Brown, M. Christian;Vetter, Douglas E.
通讯作者：
Vetter, Douglas E.