Extracellular Fluid Content in the Legs of Patients with Chronic Venous Disease
Extracellular Fluid Content in the Legs of Patients with Chronic Venous Disease
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DOI：
10.1016/j.avsg.2020.07.046
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发表时间：
2021-02-17
影响因子：
1.5
通讯作者：
Hamano, Kimikazu
中科院分区：
文献类型：
--
作者：
Suehiro, Kotaro;Morikage, Noriyasu;Hamano, Kimikazu
背景资料：本研究旨在确定影响慢性静脉疾病（CVD）患者腿部细胞外液（ECF）含量的因素。方法：对2016年9月至2019年3月期间来我院就诊的79名CVD患者进行了生物阻抗分析和空气体积描记术（APG）。并对14名健康志愿者的正常右腿（N）进行了比较。用下肢ECF阻力（Re）与上肢ECF阻力的比值（ReL/ReA）来表示受试下肢的ECF含量。结果：ReL/ReA值随CEAP分级的增加而降低（N：中位数; 0.81 [范围0.66-0.95]，CO-1：0.79 [0.60-0.98]，C2：0.77 [0.56-1.08]，C3：0.67 [0.57-0.85]，C4：0.64 [0.44-0.89]）。年龄大，女性，CEAP类影响ReL/ReA，但体重指数没有。ReL/ReA没有相关的参数，来自APG，包括静脉充盈index.Conclusions：我们发现，ECF内容在腿部的CVD患者可能主要受患者相关因素和CEAP类，而不是静脉血流动力学。
Background: This study aimed to determine the factors that affect the extracellular fluid (ECF) content in the legs of patients with chronic venous disease (CVD).Methods: Bioimpedance analysis and air plethysmography (APG) were performed in 79 patients with CVD who visited our clinic between September 2016 and March 2019. The normal right legs (N) of 14 healthy volunteers were also reviewed for comparison. The ratio of ECF resistance (Re) of the leg to that of the arm (ReL/ReA) was used to express the ECF content in the tested leg. The severity of CVD was expressed using the clinical, etiological, anatomical, and pathophysiological (CEAP) classification.Results: The ReL/ReA decreased as the CEAP class increased (N: median; 0.81 [range 0.66-0.95], CO-1: 0.79 [0.60-0.98], C2: 0.77 [0.56-1.08], C3: 0.67 [0.57-0.85], C4: 0.64 [0.44-0.89]). Older age, female sex, and CEAP class affected the ReL/ReA, but body mass index did not. The ReL/ReA did not correlate with the parameters that were derived from APG, including the venous filling index.Conclusions: We found that the ECF content in legs of patients with CVD might be primarily affected by patient-related factors and CEAP class, as opposed to venous hemodynamics.