Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality
Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality
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DOI：
10.1016/j.medengphy.2006.11.002
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发表时间：
2007-12-01
影响因子：
2.2
通讯作者：
Boyd, Steven K.
中科院分区：
文献类型：
--
作者：
MacNeil, Joshua A.;Boyd, Steven K.
三维高分辨率外周活体定量CT(HR-pQCT)(XtremeCT，瑞士Sanco Medical，体素大小为82微米)的引入为纵向监测微结构骨变化提供了一种新的方法。通过与微型计算机断层扫描(MU CT)和双能X线骨密度仪(DXA)的比较，确定HR-pQCT对骨质量的三个重要决定因素，包括骨密度(BMD)、建筑测量和骨力学的准确性。用3种方法对10具低骨量身体的40个测量数据进行扫描，并对3D数据进行图像配准，以确保相同区域的分析。DXA的面骨密度与HR-pQCT的体积骨密度有很好的相关性(R2=0.69)，当评估无量纲骨矿物含量时，相关性有所改善(R2=0.80)。在标准患者分析中，HR-pQCT测量的形态参数，包括骨体积比、骨小梁数目、骨小梁厚度、骨小梁间距和皮质厚度与MU CT测量结果有很好的相关性(R2=0.59~0.96)。此外，一些非度量参数，如连接密度(R-2=0.90)表现良好。由于分辨率的差异，HR-pQCT图像的有限元分析评估的机械硬度通常高于LCT数据，并且在连续水平上相关性很好(R-2=0.73)。在这里，HR-pQCT与金标准MU CT和DXA的验证提供了对系统准确性的洞察，并建议除了标准患者方案外，包括连接密度和机械刚度在内的其他骨质量指标可能适合作为临床骨质量监测的标准患者分析的一部分(C)2006 IPEM。爱思唯尔有限公司出版。保留所有权利。
The introduction of three-dimensional high-resolution peripheral in vivo quantitative computed tomography (HR-pQCT) (XtremeCT, Scanco Medical, Switzerland; voxel size 82 mu m) provides a new approach to monitor micro-architectural bone changes longitudinally. The accuracy of HR-pQCT for three important determinants of bone quality, including bone mineral density (BMD), architectural measurements and bone mechanics, was determined through a comparison with micro-computed tomography (mu CT) and dual energy X-ray absorptiometry (DXA). Forty measurements from 10 cadaver radii with low bone mass were scanned using the three modalities, and image registration was used for 3D data to ensure identical regions were analyzed.The areal BMD of DXA correlated well with volumetric BMD by HR-pQCT despite differences in dimensionality (R-2 = 0.69), and the correlation improved when non-dimensional bone mineral content was assessed (R-2 = 0.80). Morphological parameters measured by HR-pQCT in a standard patient analysis, including bone volume ratio, trabecular number, derived trabecular thickness, derived trabecular separation, and cortical thickness correlated well with mu CT measures (R-2 = 0.59-0.96). Additionally, some non-metric parameters such as connectivity density (R-2 = 0.90) performed well. The mechanical stiffness assessed by finite element analysis of HR-pQCT images was generally higher than for LCT data due to resolution differences, and correlated well at the continuum level (R-2 = 0.73).The validation here of HR-pQCT against gold-standards mu CT and DXA provides insight into the accuracy of the system, and suggests that in addition to the standard patient protocol, additional indices of bone quality including connectivity density and mechanical stiffness may be appropriate to include as part of a standard patient analysis for clinical monitoring of bone quality (C) 2006 IPEM. Published by Elsevier Ltd. All rights reserved.