Measurement of fiber orientation distributions using high angular resolution diffusion imaging
Measurement of fiber orientation distributions using high angular resolution diffusion imaging
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DOI：
10.1002/mrm.20667
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发表时间：
2005-11-01
影响因子：
3.3
通讯作者：
Anderson, AW
中科院分区：
文献类型：
--
作者：
Anderson, AW
扩散的高角分辨率测量用于估计体素中纤维的角分布和扩散各向异性。一个简单的，轴对称的扩散模型在白色物质纤维被用来与扩散测量纤维性能。新技术被称为纤维取向估计使用连续轴对称张量（预测）。使用数值模拟和体内测量进行测试。新方法在包含单纤维的体素中与其他方法一致，但至少在本研究中使用的扩散加权水平（tr（B）= 1480 s/mm（2））下更好地解决了交叉纤维。模型的简化假设进行了测试，通过比较与“无模型”的q球分析的体内数据和结果显示是在良好的协议。新方法解决了扩散张量成像中部分体积平均的问题，并为更可靠地估计纤维取向和分数各向异性提供了基础。Magn Reson Med 54：1194-1206，2005. (c)2005 Wiley-Liss，Inc.
High angular resolution measurements of diffusion are used to estimate the angular distribution and diffusion anisotropy of fibers in a voxel. A simple, axially symmetric model of diffusion in white matter fibers is used to relate diffusion measurements to fiber properties. The new technique is called fiber orientation estimated using continuous axially symmetric tensors (FORECAST). It is tested using both numerical simulation and in vivo measurements. The new method agrees with other methods in voxels containing single fibers, but resolves crossing fibers better, at least at the level of diffusion weighting used in this study (tr(b) = 1480 s/mm(2)). The simplifying assumptions of the model are tested by comparison with the "model-free" q-ball analysis of in vivo data and the results are shown to be in good agreement. The new method addresses the problem of partial volume averaging in diffusion tensor imaging and provides a basis for more reliable estimates of fiber orientation and fractional anisotropy. Magn Reson Med 54:1194-1206, 2005. (c) 2005 Wiley-Liss, Inc.