Incidence survey of Kawasaki disease in 1997 and 1998
Incidence survey of Kawasaki disease in 1997 and 1998
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DOI：
10.1111/j.1442-200x.2006.02221.x
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发表时间：
2006-08-01
影响因子：
1.4
通讯作者：
Kayaba, Kazunori
中科院分区：
文献类型：
--
作者：
Yanagawa, Hiroshi;Nakamura, Yosikazu;Kayaba, Kazunori
背景资料：本研究的目的是描述1999- 2002年全国川崎流行病学调查的结果。这两项调查中报告的患者均为两个研究期间（1999-2000年和2001-2002年）报告的新患者，尽管数据是回顾性收集的。向日本全国所有拥有100张床位或更多床位的医院的儿科发送了一份调查问卷，要求提供川崎患者的数据，如性别、年龄、首次住院日期、复发和心脏病变。1999-2002年4年期间报告的患者总数为32266例（男性18604例，女性13662例），平均年发病率为每100000名5岁以下儿童中有137.7例。男女比例为1.30。发病高峰在9-11月龄，1岁以下患者比例为26%。各月分布在1月份有一个高峰，夏季逐渐增加。从地理上看，高发区仅限于某些县，而且每年都在转移。急性期心脏损害和心脏后遗症多见于1岁以下和4岁以上儿童。主要症状以发热≥ 5天最常见，其次为结膜充血、口唇改变、多形性外眦赘皮和四肢改变。结论：1999-2002年全国发病率调查共报告川崎患者32 000余例。尽管儿童人数减少，但患者人数仍在稳步增加。季节性变化、地理分布和年龄特异性分布支持川崎病的感染学说。
Background : The purpose of the present study was to describe the results of nationwide epidemiologic surveys of Kawasaki disease for the 4 year period 1999-2002.Methods : The design is a retrospective incidence survey. The patients reported in these two surveys are all new patients who were reported during the two study periods (1999-2000 and 2001-2002), although the data were collected retrospectively. A questionnaire was sent to all pediatric departments of hospitals with 100 beds or more throughout Japan, requesting data on patients with Kawasaki disease, such as sex, age, date of first hospital visit, recurrence, and cardiac lesions.Results : The total number of patients reported in the 4 year period 1999-2002 was 32 266 (18 604 male, 13 662 female), with an average annual incidence of 137.7 per 100 000 children younger than 5 years old. The male/female ratio was 1.30. The incidence peaked at 9-11 months of age, and the proportion of patients under 1 year of age was 26%. The monthly distribution had a high peak in January and a gradual increase in summer. Geographically, the high-incidence areas were limited to certain prefectures and moved from year to year. The cardiac lesions at acute stage and cardiac sequelae occurred more in children under 1 year and older than 4 years. Among the principal symptoms, fever persisting >= 5 days occurred most commonly, followed by conjunctival congestion, changes in lips and oral cavity, polymorphous exanthema, and changes of extremities. Cervical lymphadenopathy occurred less.Conclusion : More than 32 000 patients with Kawasaki disease during the 4 year period 1999-2002 were reported to the nationwide incidence surveys. The number of patients is steadily increasing despite the decrease of children. The seasonal variation, geographical distribution, and age-specific distribution support the infection theory for the etiology of Kawasaki disease.