Total synthesis of lobatoside E, a potent antitumor cyclic triterpene saponin.
Total synthesis of lobatoside E, a potent antitumor cyclic triterpene saponin.
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DOI：
10.1021/ja801669r
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发表时间：
2008-04
影响因子：
15
通讯作者：
C. Zhu;P. Tang;Biao Yu
中科院分区：
文献类型：
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作者：
C. Zhu;P. Tang;Biao Yu
Lobatoside E是一种新型的复杂环三萜皂苷，具有有效的抗肿瘤活性，首次合成，采用高度模块化的方法。以齐墩果酸、d -葡萄糖、d -半乳糖、l -阿拉伯糖和l -鼠李糖为起始原料，共需73步，最长线性序列为31步，总产率为1.2%。
Lobatoside E, a novel and complex cyclic triterpene saponin showing potent antitumor activities, has been synthesized for the first time, employing a highly modular approach. The synthesis, starting with oleanolic acid, D-glucose, D-galactose, L-arabinose, and L-rhamnose, requires a total of 73 steps, with the longest linear sequence of 31 steps and in 1.2% overall yield.