Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks
Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks
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DOI：
10.1016/s0278-6915(03)00187-x
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发表时间：
2003-11-01
影响因子：
4.3
通讯作者：
Peters, PWJ
中科院分区：
文献类型：
--
作者：
Konings, EJM;Baars, AJ;Peters, PWJ
2002年4月底，瑞典食品管理局报告说，热处理食品中含有丙烯酰胺。丙烯酰胺已被证明是有毒和致癌的动物，并已被世界卫生组织/国际癌症研究机构等列为“可能致癌的人类”。本研究的目的是首先分析丙烯酰胺含量的最重要的食物有助于这种曝光，其次，估计丙烯酰胺曝光在荷兰人口的代表性样本，第三，估计这种消费的公共健康风险。我们用LC-MS-MS方法分析了食品中丙烯酰胺的含量。结果，然后被用来估计谁参加了1998年全国食品消费调查（NFCS）的消费者（n = 6250）的丙烯酰胺暴露。使用概率方法估计了荷兰总人口和几个年龄组的暴露量。在344种食品中，丙烯酰胺含量从< 30至3100微克/公斤不等。平均丙烯酰胺含量最高的食物是薯片（1249 mug/kg），薯条（油炸）（351 mug/kg），鸡尾酒小吃（1060 mug/kg）和姜饼（890 mug/kg）。NFCS参与者的平均丙烯酰胺暴露量为0.48 mug/kg bw/天。神经毒性风险可忽略不计。从接触估计来看，额外的癌症风险似乎不可忽略。(C)2003爱思唯尔有限公司。保留所有权利。
At the end of April 2002, the Swedish Food Administration reported the presence of acrylamide in heat treated food products. Acrylamide has been shown to be toxic and carcinogenic in animals, and has been classified by the WHO/IARC among others as 'probably carcinogenic for humans'. The purposes of this study were firstly to analyse acrylamide contents of the most important foods contributing to such exposure, secondly, to estimate the acrylamide exposure in a representative sample of the Dutch population, and thirdly to estimate the public health risks of this consumption. We analysed the acrylamide content of foods with an LC-MS-MS method. The results were then used to estimate the acrylamide exposure of consumers who participated in the National Food Consumption Survey (NFCS) in 1998 (n = 6250). The exposure was estimated using the probabilistic approach for the total Dutch population and several age groups. For 344 food products, acrylamide amounts ranged from < 30 to 3100 mug/kg. Foods with the highest mean acrylamide amounts were potato crisps (1249 mug/kg), chips (deep-fried) (351 mug/kg), cocktail snacks (1060 mug/kg), and gingerbread (890 mug/kg). The mean acrylamide exposure of the NFCS participants was 0.48 mug/kg bw/day. Risk of neurotoxicity is negligible. From exposure estimations it appears that the additional cancer risk might not be negligible. (C) 2003 Elsevier Ltd. All rights reserved.