Distinct prognostic values of YAP1 in gastric cancer
Distinct prognostic values of YAP1 in gastric cancer
复制标题
YAP1 在胃癌中的独特预后价值
DOI：
10.1177/1010428317695926
复制
发表时间：
2017-04-01
期刊：
影响因子：
--
通讯作者：
Ma, Ding
中科院分区：
文献类型：
--
作者：
Yu, Lan;Gao, Chun;Ma, Ding
Hippo 通路通过调节细胞凋亡和细胞增殖来调节内在器官的大小。 YAP1（yes 相关蛋白 1）是 Hippo 通路的转录效应子。据报道，YAP1 表达与胃癌的癌变和恶性肿瘤相关。在本研究中，我们比较了YAP1在胃癌和正常胃组织中的表达。对 156 个胃癌样本、8 个邻近正常胃组织和 4 个正常胃组织进行组织微阵列分析。我们还分析了 YAP1 蛋白表达与临床病理特征（如年龄、性别、组织学分化和临床分期）之间的关联。我们使用 ONCOMINE 数据库和 Kaplan-Meier 绘图仪分析胃癌不同临床病理参数中 YAP1 的表达状态。我们还使用Kaplan-Meier绘图仪总结了总共631名胃癌患者的YAP1生存信息。与正常胃组织相比，YAP1在胃癌组织中表达升高。与胃粘膜相比，YAP1 信使 RNA 在胃肠型腺癌和胃混合腺癌中表达上调。研究发现，YAP1 高表达与随访 20 年的所有胃癌患者的总生存期较差相关。这些结果表明YAP1可用于预测胃癌的预后。 YAP1可能是胃癌患者的潜在药物靶点。
The Hippo pathway regulates intrinsic organ sizes by regulating apoptosis and cell proliferation. YAP1 (yes-associated protein 1) is a transcriptional effector of the Hippo pathway. YAP1 expression is reported to be associated with gastric cancer carcinogenesis and malignancy. In this study, we compared the expression of YAP1 in gastric cancer and normal stomach tissues. Tissue microarray analysis was performed in 156 gastric cancer samples, 8 adjacent normal stomach tissues, and 4 normal stomach tissues. We also analyzed the association between YAP1 protein expression and clinicopathological features, such as age, gender, histological differentiation, and clinical stages. We used the ONCOMINE database and the Kaplan–Meier plotter to analyze YAP1 expression status in different clinicopathological parameters of gastric cancer. We also used the Kaplan–Meier plotter to summarize the survival information of YAP1 from a total of 631 gastric cancer patients. YAP1 expression was found to be elevated in gastric cancer tissues compared to normal stomach tissues. YAP1 messenger RNA was found to be upregulated in gastric intestinal-type adenocarcinoma and gastric mixed adenocarcinoma compared to gastric mucosa. YAP1 high expression was found to be correlated to worse overall survival for all gastric cancer patients followed for 20 years. These results indicate that YAP1 can be used to predict the prognosis of gastric cancer. And YAP1 maybe a potential drug target for gastric cancer patients.