Classifying Antiarrhythmic Actions: By Facts or Speculation
Classifying Antiarrhythmic Actions: By Facts or Speculation
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DOI：
10.1002/j.1552-4604.1992.tb03797.x
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发表时间：
1992-11
期刊：
影响因子：
--
通讯作者：
E. Williams
中科院分区：
文献类型：
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作者：
E. Williams
根据心脏心律失常抑制试验的结果，对抗心律失常作用的分类进行了综述，并对最近发表的6种分类方法(西西里游戏)进行了详细讨论。当剔除投机因素后，另一种分类被证明与原来的分类相似。声称该分类未能预测抗心律失常药物的疗效，为选择合适的治疗方法提供了依据，并通过实例进行了检验。西比林的抗心律失常作用于1980年被分类。对过去十年的验证性实验和临床试验的详细回顾表明，当时的预测与后来的结果一致。对药物对功能心脏组织的实际影响进行分类，为根据诊断找到特定心律失常的首选治疗方法提供了合理的基础。
Classification of antiarrhythmic actions is reviewed in the context of the results of the Cardiac Arrhythmia Suppression Trials, CAST 1 and 2. Six criticisms of the classification recently published (The Sicilian Gambit) are discussed in detail. The alternative classification, when stripped of speculative elements, is shown to be similar to the original classification. Claims that the classification failed to predict the efficacy of antiarrhythmic drugs for the selection of appropriate therapy have been tested by an example. The antiarrhythmic actions of cibenzoline were classified in 1980. A detailed review of confirmatory experiments and clinical trials during the past decade shows that predictions made at the time agree with subsequent results. Classification of the effects drugs actually have on functioning cardiac tissues provides a rational basis for finding the preferred treatment for a particular arrhythmia in accordance with the diagnosis.