Nystagmus during an acute Meniere's attack: from prodrome to recovery
Nystagmus during an acute Meniere's attack: from prodrome to recovery
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DOI：
10.1080/14992027.2020.1799252
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发表时间：
2020-07-30
影响因子：
2.7
通讯作者：
FitzGerald, John
中科院分区：
文献类型：
--
作者：
Phillips, John S.;Newman, Jacob L.;FitzGerald, John
目的我们目前正在进行一项临床研究，以评估一个系统的诊断能力，检测周期的病理性头晕。本文介绍了梅尼埃病急性发作期间捕获的数据分析。设计连续动态前庭评估（CAVA）设备由社区中的患者佩戴，并连续记录眼睛和头部运动数据（前庭遥测）。研究样本：一名53岁女性，有15年左侧单侧梅尼埃病史。结果患者几乎连续佩戴该装置30天。数据显示，眩晕发作长达三小时，包括四个独立的眼球震颤阶段。眼球震颤的持续时间、搏动方向和慢相速度随时间演变。第一阶段包含孤立的眼球震颤搏动，其在患者记录眩晕发作发作之前，但与即将发生的眩晕发作的预期一致。结论CAVA提供了一个独特的洞察头晕发作期间存在的生理参数。在这里，它提供了第一个完整的例子，急性梅尼埃的攻击，包括一个时期的前驱症状。这些发现对眩晕发作的预测、梅尼埃病和其他导致眩晕的疾病的诊断具有意义。
Objective We are currently undertaking a clinical investigation to evaluate the diagnostic capability of a system for detecting periods of pathological dizziness. This article presents an analysis of the data captured during an acute attack of Meniere's disease. Design The Continuous Ambulatory Vestibular Assessment (CAVA) device is worn by patients in the community, and continuously records eye and head movement data (vestibular telemetry). Study sample A 53-year-old lady with a fifteen-year history of left-sided unilateral Meniere's disease. Results The patient wore the device nearly continuously for thirty days. The data revealed a three-hour long attack of vertigo consisting of four separate phases of nystagmus. The duration, beat-direction and slow phase velocity of the nystagmus evolved through time. The first phase contained isolated nystagmus beats which preceded the patient's record of the vertigo attack onset but coincided with anticipation of an impending vertigo attack. Conclusions CAVA provides a unique insight into the physiological parameters present during episodes of dizziness. Here, it has provided the first full example of an acute Meniere's attack, including a period of prodrome. These findings have implications for the prediction of vertigo attack onset, for the diagnosis of Meniere's disease and other diseases resulting in dizziness.